Femoral biomechanic and microtomography from male rats submitted to dietary restriction supplemented with sucrose

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dc.contributor.authorCarvalho, A. A.F.
dc.contributor.authorBiffe, B. G.
dc.contributor.authorNakamune, Ana Cláudia de Melo Stevanato [UNESP]
dc.contributor.authorLouzada, M. J.Q.
dc.contributor.institutionAraçatuba Dental School
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionMedicine Veterinarian School at Araçatuba
dc.date.accessioned2022-04-29T08:44:44Z
dc.date.available2022-04-29T08:44:44Z
dc.date.issued2013-10-23
dc.description.abstractFood restriction reduces body weight and influence bone mass and also is correlated with bone mineral density (BMD). Mechanisms have been proposed for the loss of BMD after body weight reduction, including reduced energy intake. Growing 8 wk-old Wistar male rats were randomly divided into Control and Calorie restriction associated with sucrose 30% (CRS). These animals were subjected to intermittent food restriction during 8 weeks and had free access to tap water and sucrose30% in distilled water. The rats were euthanized at the end of week 8, blood collected from abdominal aorta artery, femurs cleaned of adherent soft tissues, scanned using dual energy X-ray absorptiometry, structural and material properties determined by three-point bending testing in the mid-diaphyseal region, bone surface tested in a microhardness tester and microstructure was assessed in a microcomputer tomography. In CRS animals body weight decreased significantly relative to the Control animals. There was a clear option for high-sucrose beverage in CRS animals. No difference was observed in biochemical, densitometric and biomechanical analyzes. Results from micro CT showed only significant difference in connectivity of trabecular bone. It has been suggested that rats submitted to food restriction consumed sugar not because of its inherent palatability, but in order to alter their macronutrient balance and animals need to meet energy demands in high-sucrose.en
dc.description.affiliationDepartment of Pathology Araçatuba Dental School, CEP 16015-050, Araçatuba, SP
dc.description.affiliationDepartment of Physiology Sciences Federal University of São Carlos - UFSCar, São Carlos, SP
dc.description.affiliationDepartment of Basic Sciences Araçatuba Dental School, CEP 16015-050, Araçatuba, SP
dc.description.affiliationDepartment of Support, Production and Animal Health Medicine Veterinarian School at Araçatuba, CEP 16015-050, Araçatuba, SP
dc.format.extent176-181
dc.identifier.citationJournal of Morphological Sciences, v. 30, n. 3, p. 176-181, 2013.
dc.identifier.issn2177-0298
dc.identifier.scopus2-s2.0-84885721070
dc.identifier.urihttp://hdl.handle.net/11449/231306
dc.language.isoeng
dc.relation.ispartofJournal of Morphological Sciences
dc.sourceScopus
dc.subjectBone mineral density
dc.subjectFemoral biomechanics
dc.subjectFemoral microtomography
dc.subjectFood restriction
dc.titleFemoral biomechanic and microtomography from male rats submitted to dietary restriction supplemented with sucroseen
dc.typeArtigo

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Artigos - Patologia e Propedêutica Clínica - FOA
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