Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers

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dc.contributor.authorHara, Cristiane De Castro Pernet [UNESP]
dc.contributor.authorFran�a, Eduardo Luz�a
dc.contributor.authorFagundes, Danny Laura Gomes
dc.contributor.authorDe Queiroz, Adriele Ataides
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorHonorio-Fran�a, Adenilda Cristina
dc.contributor.authorCalderon, Iracema De Mattos Paranhos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Mato Grosso
dc.date.accessioned2018-12-11T17:03:14Z
dc.date.available2018-12-11T17:03:14Z
dc.date.issued2016-01-01
dc.description.abstractThe present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16+CD56- NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56- and CD16-CD56+. The placental extravillous layer of GDM and DM-2 showed an increase of CD16+CD56- cells and, irrespective of region, the proportion of CD16-CD56+ cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2. IL-2 was lower in maternal blood and IFN-γ higher in maternal and cord blood from the GDM group. IL-17 was higher in maternal and cord blood from the DM-2 group. The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-γ and low levels of IL-1β and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-γ. The GDM group, irrespective of region, showed higher levels of IL-8. The DM-2 group, irrespective of region, placenta showed high levels of TNF-α, IL-17, and IFN-γ. The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16+.en
dc.description.affiliationGraduate Program in Gynecology Obstetrics and Mastology Botucatu Medical School S�o Paulo State University (UNESP)
dc.description.affiliationInstitute of Biological and Health Science Federal University of Mato Grosso
dc.description.affiliationUnespGraduate Program in Gynecology Obstetrics and Mastology Botucatu Medical School S�o Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/24212-4
dc.description.sponsorshipIdFAPESP: 2013/13017-9
dc.identifierhttp://dx.doi.org/10.1155/2016/7154524
dc.identifier.citationJournal of Immunology Research, v. 2016.
dc.identifier.doi10.1155/2016/7154524
dc.identifier.file2-s2.0-84973124868.pdf
dc.identifier.issn2314-7156
dc.identifier.issn2314-8861
dc.identifier.lattes6758680388835078
dc.identifier.scopus2-s2.0-84973124868
dc.identifier.urihttp://hdl.handle.net/11449/173039
dc.language.isoeng
dc.relation.ispartofJournal of Immunology Research
dc.relation.ispartofsjr1,352
dc.relation.ispartofsjr1,352
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleCharacterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothersen
dc.typeArtigo
unesp.author.lattes6758680388835078

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