Cymbopogon martinii essential oil and geraniol at noncytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytes

Página do item simplificado
dc.contributor.authorMurbach Teles Andrade, Bruna Fernanda [UNESP]
dc.contributor.authorConti, Bruno Jose [UNESP]
dc.contributor.authorSantiago, Karina Basso [UNESP]
dc.contributor.authorFernandes Junior, Ary [UNESP]
dc.contributor.authorSforcin, Jose Mauricio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:55:17Z
dc.date.available2015-03-18T15:55:17Z
dc.date.issued2014-10-01
dc.description.abstractObjectivesIn traditional medicine, plants have formed the basis of sophisticated systems that have been in existence for thousands of years and still provide mankind with new remedies. Cymbopogon martinii, known as palmarosa, has been used in aromatherapy as a skin tonic due to its antimicrobial properties. It has also used in Ayurvedic medicine for skin problems and to relieve nerve pain. The immunomodulatory action of C.martinii essential oil (EO) and geraniol was evaluated regarding the production of pro- and anti-inflammatory cytokines (tumour necrosis factor (TNF)- and IL-10, respectively) by human monocytes in vitro.MethodsMonocyte cultures were incubated with EO or geraniol. After 18h, cytotoxicity assays were performed using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide method, and cytokine production was determined by ELISA.Key findingsThe variables showed no cytotoxic effects on monocytes. TNF- production was not affected by C.martinii and geraniol, and only the concentration of 5g/ml of C.martinii stimulated its production. On the other hand, all concentrations of C.martinii and geraniol increased IL-10 production by human monocytes.ConclusionsData showed that noncytotoxic concentrations of EO and geraniol exerted an anti-inflammatory action by increasing IL-10 production; moreover, geraniol seemed to be probably responsible for EO immunomodulatory activity in our assay condition.en
dc.description.affiliationUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, Brazil
dc.format.extent1491-1496
dc.identifierhttp://dx.doi.org/10.1111/jphp.12278
dc.identifier.citationJournal Of Pharmacy And Pharmacology. Hoboken: Wiley-blackwell, v. 66, n. 10, p. 1491-1496, 2014.
dc.identifier.doi10.1111/jphp.12278
dc.identifier.issn0022-3573
dc.identifier.urihttp://hdl.handle.net/11449/117140
dc.identifier.wosWOS:000342799200014
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Pharmacy And Pharmacology
dc.relation.ispartofjcr2.309
dc.relation.ispartofsjr0,657
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCymbopogon martiniien
dc.subjectcytokinesen
dc.subjectessential oilen
dc.subjectgeraniolen
dc.subjectmonocytesen
dc.titleCymbopogon martinii essential oil and geraniol at noncytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes8310835825824360[4]
unesp.author.orcid0000-0002-2744-2824[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

Arquivos

Coleções

Artigos - Microbiologia e Imunologia - IBB