Natural killer activity in mice infected with rabies virus and submitted to P-acnes (Propionibacterium acnes) as immunomodulator

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dc.contributor.authorMegid, Jane [UNESP]
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:38:11Z
dc.date.available2014-05-20T13:38:11Z
dc.date.issued2000-03-01
dc.description.abstractThe natural killer (NK) activity and lethality were evaluated in swiss mice experimentally infected with street rabies virus and submitted to immunomodulation by P. acnes (formerly Corynebacterium parvum). The infected animals were sacrificed at different times and spleen non-adherent cells were obtained through ficoll-hypaque gradient and depletion of glass-adherent cells. Immunosuppression was observed in rabies virus infected mice correlated with lower NK activity in clinically ill animals. Higher NK activity and percentual of survival were observed in the group submitted to P. acnes. The increased survival correlated with higher NK activity induced by P. acnes suggests a protective role of this natural barrier against rabies virus infection in mice. (C) 2000 Elsevier B.V. Ltd. All rights reserved.en
dc.description.affiliationUNESP, Fac Med Vet, Dept Vet Hyg & Publ Hlth, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Microbiol & Immunol, Inst Biol Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Med Vet, Dept Vet Hyg & Publ Hlth, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Microbiol & Immunol, Inst Biol Sci, BR-18618000 Botucatu, SP, Brazil
dc.format.extent91-97
dc.identifierhttp://dx.doi.org/10.1016/S0147-9571(99)00061-2
dc.identifier.citationComparative Immunology Microbiology and Infectious Diseases. Oxford: Pergamon-Elsevier B.V., v. 23, n. 2, p. 91-97, 2000.
dc.identifier.doi10.1016/S0147-9571(99)00061-2
dc.identifier.issn0147-9571
dc.identifier.lattes8845835550637809
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.urihttp://hdl.handle.net/11449/13249
dc.identifier.wosWOS:000084770300002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Immunology Microbiology and Infectious Diseases
dc.relation.ispartofjcr1.920
dc.relation.ispartofsjr0,877
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectrabiespt
dc.subjectnatural killer cellspt
dc.subjectimmunomodulatorpt
dc.subjectPropionibacterium acnespt
dc.titleNatural killer activity in mice infected with rabies virus and submitted to P-acnes (Propionibacterium acnes) as immunomodulatoren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes8845835550637809[2]
unesp.author.orcid0000-0002-6540-7157[1]
unesp.author.orcid0000-0002-4292-3298[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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