Commissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidine

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dc.contributor.authorTotola, L. T.
dc.contributor.authorAlves, T. B.
dc.contributor.authorTakakura, A. C.
dc.contributor.authorFerreira-Neto, H. C.
dc.contributor.authorAntunes, V. R.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorMoreira, T. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:47Z
dc.date.available2014-05-27T11:30:47Z
dc.date.issued2013-10-01
dc.description.abstractThe rostral ventrolateral medulla (RVLM) contains the presympathetic neurons involved in cardiovascular regulation that has been implicated as one of the most important central sites for the antihypertensive action of moxonidine (an α2-adrenergic and imidazoline agonist). Here, we sought to evaluate the cardiovascular effects produced by moxonidine injected into another important brainstem site, the commissural nucleus of the solitary tract (commNTS). Mean arterial pressure (MAP), heart rate (HR), splanchnic sympathetic nerve activity (sSNA) and activity of putative sympathoexcitatory vasomotor neurons of the RVLM were recorded in conscious or urethane-anesthetized, and artificial ventilated male Wistar rats. In conscious or anesthetized rats, moxonidine (2.5 and 5. nmol/50. nl) injected into the commNTS reduced MAP, HR and sSNA. The injection of moxonidine into the commNTS also elicited a reduction of 28% in the activity of sympathoexcitatory vasomotor neurons of the RVLM. To further assess the notion that moxonidine could act in another brainstem area to elicit the antihypertensive effects, a group with electrolytic lesions of the commNTS or sham and with stainless steel guide-cannulas implanted into the 4th V were used. In the sham group, moxonidine (20. nmol/1. μl) injected into 4th V decreased MAP and HR. The hypotension but not the bradycardia produced by moxonidine into the 4th V was reduced in acute (1. day) commNTS-lesioned rats. These data suggest that moxonidine can certainly act in other brainstem regions, such as commNTS to produce its beneficial therapeutic effects, such as hypotension and reduction in sympathetic nerve activity. © 2013 IBRO.en
dc.description.affiliationDepartment of Physiology and Biophysics Institute of Biomedical Science University of São Paulo, São Paulo, SP
dc.description.affiliationDepartment of Pharmacology Institute of Biomedical Science University of São Paulo, São Paulo, SP
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry Sao Paulo State University, Araraquara, SP
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry Sao Paulo State University, Araraquara, SP
dc.format.extent80-91
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2013.06.065
dc.identifier.citationNeuroscience, v. 250, p. 80-91.
dc.identifier.doi10.1016/j.neuroscience.2013.06.065
dc.identifier.issn0306-4522
dc.identifier.issn1873-7544
dc.identifier.lattes1023597870118105
dc.identifier.lattes4544450092427426
dc.identifier.scopus2-s2.0-84881108411
dc.identifier.urihttp://hdl.handle.net/11449/76728
dc.identifier.wosWOS:000324847400008
dc.language.isoeng
dc.relation.ispartofNeuroscience
dc.relation.ispartofjcr3.382
dc.relation.ispartofsjr1,602
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCommissural NTS
dc.subjectMoxonidine
dc.subjectSympathetic activity hypertension
dc.subject2 (2 methoxy 1,4 benzodioxan 2 yl) 2 imidazoline
dc.subjectmoxonidine
dc.subjecturethan
dc.subjectyohimbine
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectantihypertensive activity
dc.subjectbrain commissure
dc.subjectbrain fourth ventricle
dc.subjectbrain region
dc.subjectcontrolled study
dc.subjectdrug mechanism
dc.subjectexperimental rat
dc.subjectheart rate
dc.subjecthypotension
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectnerve conduction
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectsolitary tract nucleus
dc.subjectsplanchnic nerve
dc.subjectsympathetic nerve
dc.subjectthalamus ventral nucleus
dc.titleCommissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes1023597870118105
unesp.author.lattes4544450092427426[7]
unesp.author.orcid0000-0002-1395-4036[7]
unesp.author.orcid0000-0003-1167-4441[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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