DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

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dc.contributor.authorPaes, Ellen Regina Da Costa
dc.contributor.authorBraz, Mariana Gobbo [UNESP]
dc.contributor.authorLima, Joilson Teixeira De
dc.contributor.authorSilva, Milana Reis Gomes Da
dc.contributor.authorSousa, Leilane Bentes De
dc.contributor.authorLima, Emerson Silva
dc.contributor.authorVasconcellos, Marne Carvalho De
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.institutionFederal University of Amazonas Faculty of Pharmaceutical Sciences
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Amazonas (UFAM)
dc.date.accessioned2014-10-01T13:08:33Z
dc.date.available2014-10-01T13:08:33Z
dc.date.issued2014-04-01
dc.description.abstractPURPOSE:To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency. METHODS:The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isoflurane and to a lesser degree to sevoflurane and nitrous oxide; the control group consisted of 15 young adults not exposed to anesthetics. Blood samples were drawn from professionals during medical residency (eight, 16 and 22 months of exposure to waste anesthetic gases). DNA damage was evaluated by comet assay, and antioxidant defense was assessed by total thiols and the enzymes glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). RESULTS:When comparing the two groups, DNA damage was significantly increased at all time points evaluated in the exposed group; plasma thiols increased at 22 months of exposure and GPX was higher at 16 and 22 months of exposure. CONCLUSION:Young professionals exposed to waste anesthetic gases in operating rooms without adequate scavenging system have increased DNA damage and changes in redox status during medical residency. There is a need to minimize exposure to inhalation anesthetics and to provide better work conditions.en
dc.description.affiliationFederal University of Amazonas Faculty of Pharmaceutical Sciences
dc.description.affiliationUNESP Botucatu Medical School Department of Anesthesiology
dc.description.affiliationUFAM Faculty of Pharmaceutical Sciences
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Anesthesiology
dc.format.extent280-286
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014000400010
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, n. 4, p. 280-286, 2014.
dc.identifier.doi10.1590/S0102-86502014000400010
dc.identifier.fileS0102-86502014000400280.pdf
dc.identifier.issn0102-8650
dc.identifier.lattes5530023010203804
dc.identifier.orcid0000-0003-4413-226X
dc.identifier.scieloS0102-86502014000400280
dc.identifier.urihttp://hdl.handle.net/11449/109789
dc.identifier.wosWOS:000334997000010
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirúrgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectAnestheticsen
dc.subjectOccupational Exposureen
dc.subjectToxicityen
dc.titleDNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gasesen
dc.typeArtigo
unesp.author.lattes5530023010203804
unesp.author.orcid0000-0001-7785-4029[7]
unesp.author.orcid0000-0003-4413-226X[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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