Exploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter study

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dc.contributor.authorSandes-Freitas, Taina Veras de
dc.contributor.authorMazzali, Marilda
dc.contributor.authorManfro, Roberto Ceratti
dc.contributor.authorAndrade, Luis Gustavo Modelli de [UNESP]
dc.contributor.authorVicari, Alessandra Rosa
dc.contributor.authorSousa, Marcos Vinicius de
dc.contributor.authorMedina Pestana, Jose Osmar
dc.contributor.authorGarcia, Valter Duro
dc.contributor.authorCarvalho, Deise Rosa de Boni Monteiro de
dc.contributor.authorMatos Esmeraldo, Ronaldo de
dc.contributor.authorOliveira, Claudia Maria Costa de
dc.contributor.authorSimao, Denise Rodrigues
dc.contributor.authorDeboni, Luciane Monica
dc.contributor.authorDavid-Neto, Elias
dc.contributor.authorCavalcanti, Frederico Castelo Branco
dc.contributor.authorPacheco-Silva, Alvaro
dc.contributor.authorFerreira, Gustavo Fernandes
dc.contributor.authorMadeira, Rafael Lage
dc.contributor.authorBignelli, Alexandre Tortoza
dc.contributor.authorMeira, Geraldo Sergio Goncalves
dc.contributor.authorLasmar, Euler Pace
dc.contributor.authorKeitel, Elizete
dc.contributor.authorAzevedo Matuck, Tereza de
dc.contributor.authorCosta, Silvana Daher da
dc.contributor.authorNga, Hong Si [UNESP]
dc.contributor.authorFernandes, Paula Frassinetti Castelo Branco Camurca
dc.contributor.authorNarciso, Humberto Rebello
dc.contributor.authorVieira, Marcos Alexandre
dc.contributor.authorAgena, Fabiana
dc.contributor.authorFonseca, Ivailda Barbosa
dc.contributor.authorMatos, Ana Cristina Carvalho de
dc.contributor.authorBastos, Juliana
dc.contributor.authorVillaca, Sandra Simone
dc.contributor.authorHokazono, Silvia Regina
dc.contributor.authorSilva, Alberto Rafael Baleeiro
dc.contributor.authorLasmar, Marcus
dc.contributor.authorTedesco-Silva, Helio
dc.contributor.authorDGF-Brazil Study Grp
dc.contributor.institutionUniv Fed Cear
dc.contributor.institutionHosp Geral Fortaleza
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFundacao Oswaldo Ramos
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa Miserordia Porto Alegre
dc.contributor.institutionHosp Sao Francisco Providencia Deus
dc.contributor.institutionHosp Univ Walter Cantidio
dc.contributor.institutionHosp Santa Isabel
dc.contributor.institutionFundacao Prorim
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionReal Hosp Portugues Benefencia Pernambuco
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionSanta Casa Miserordia Juiz De Fora
dc.contributor.institutionHosp Felicio Rocho
dc.contributor.institutionHosp Univ Cajuru
dc.contributor.institutionSanta Casa Montes Claros
dc.contributor.institutionHosp Univ Ciencias Med
dc.contributor.institutionUniv Fed Ciencias Saude Porto Alegre
dc.date.accessioned2021-06-25T15:20:12Z
dc.date.available2021-06-25T15:20:12Z
dc.date.issued2021-04-26
dc.description.abstractThis retrospective multicenter (n = 18) cohort study evaluated the incidence, risk factors, and the impact of delayed graft function (DGF) on 1-year kidney transplant (KT) outcomes. Of 3992 deceased donor KT performed in 2014-2015, the incidence of DGF was 54%, ranging from 29.9% to 87.7% among centers. Risk factors ((lower-bound-95%CI) OR (upper-bound-95%CI)) were male gender ((1.066)1.249(1.463)), diabetic kidney disease ((1.053)1.296(1.595)), time on dialysis ((1.005)1.007(1.009)), retransplantation ((1.035)1.397(1.885)), preformed anti-HLA antibodies ((1.011)1.383(1.892)), HLA mismatches ((1.006)1.066(1.130)), donor age ((1.011)1.017(1.023)), donor final serum creatinine (sCr) ((1.239)1.317(1.399)), cold ischemia time (CIT) ((1.031)1.043(1.056)), machine perfusion ((0.401)0.542(0.733)), and induction therapy with rabbit antithymocyte globulin (rATG) ((0.658)0.800(0.973)). Duration of DGF > 4 days was associated with inferior renal function and DGF > 14 days with the higher incidences of acute rejection, graft loss, and death. In conclusion, the incidence and duration of DGF were high and associated with inferior graft outcomes. While late referral and poor donor maintenance account for the high overall incidence of DGF, variability in donor and recipient selection, organ preservation method, and type of induction agent may account for the wide variation observed among transplant centers.en
dc.description.affiliationUniv Fed Cear, Dept Med Clin, Fortaleza, CE, Brazil
dc.description.affiliationHosp Geral Fortaleza, Fortaleza, CE, Brazil
dc.description.affiliationHosp Clin Univ Campinas, Campinas, SP, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Med Interna, Botucatu, SP, Brazil
dc.description.affiliationFundacao Oswaldo Ramos, Hosp Rim, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationSanta Casa Miserordia Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Sao Francisco Providencia Deus, Rio De Janeiro, RJ, Brazil
dc.description.affiliationHosp Univ Walter Cantidio, Fortaleza, CE, Brazil
dc.description.affiliationHosp Santa Isabel, Blumenau, SC, Brazil
dc.description.affiliationFundacao Prorim, Hosp Municipal Sao Jos Joinville, Joinville, SC, Brazil
dc.description.affiliationUniv Sao Paulo, Hosp Clin, Sao Paulo, SP, Brazil
dc.description.affiliationReal Hosp Portugues Benefencia Pernambuco, Recife, PE, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
dc.description.affiliationSanta Casa Miserordia Juiz De Fora, Juiz De Fora, MG, Brazil
dc.description.affiliationHosp Felicio Rocho, Belo Horizonte, MG, Brazil
dc.description.affiliationHosp Univ Cajuru, Curitiba, PR, Brazil
dc.description.affiliationSanta Casa Montes Claros, Montes Claros, MG, Brazil
dc.description.affiliationHosp Univ Ciencias Med, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Med Interna, Botucatu, SP, Brazil
dc.description.sponsorshipAssociacao Brasileira de Transplantes de Orgaos, ABTO
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.1111/tri.13865
dc.identifier.citationTransplant International. Hoboken: Wiley, 12 p., 2021.
dc.identifier.doi10.1111/tri.13865
dc.identifier.issn0934-0874
dc.identifier.urihttp://hdl.handle.net/11449/210427
dc.identifier.wosWOS:000643915300001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofTransplant International
dc.sourceWeb of Science
dc.subjectBrazil
dc.subjectdelayed graft function
dc.subjectkidney transplant
dc.titleExploring the causes of the high incidence of delayed graft function after kidney transplantation in Brazil: a multicenter studyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0001-6297-4909[2]
unesp.author.orcid0000-0002-0280-1069[6]

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