Effects of macrocyclic lactones on the reproductive parameters of engorged Rhipicephalus (Boophilus) microplus females detached from experimentally infested cattle

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dc.contributor.authorLopes, Welber Daniel Zanetti [UNESP]
dc.contributor.authorTeixeira, Weslen Fabricio Pires [UNESP]
dc.contributor.authorde Matos, Lucas Vinicius Shigaki [UNESP]
dc.contributor.authorFelippelli, Gustavo [UNESP]
dc.contributor.authorCruz, Breno Cayeiro [UNESP]
dc.contributor.authorMaciel, Willian Giquelin [UNESP]
dc.contributor.authorBuzzulini, Carolina [UNESP]
dc.contributor.authorFávero, Flávia Carolina [UNESP]
dc.contributor.authorSoares, Vando Edésio [UNESP]
dc.contributor.authorOliveira, Gilson Pereira de [UNESP]
dc.contributor.authorda Costa, Alvimar José [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:32Z
dc.date.available2014-05-27T11:30:32Z
dc.date.issued2013-09-01
dc.description.abstractThe present study therefore assessed the deleterious effects of MLs (ivermectin, abamectin, doramectin and moxidectin) on the reproductive parameters of engorged Rhipicephalus (Boophilus) microplus females that naturally detached from experimentally infested cattle in two experiments. The following reproductive parameters of engorged female ticks were analyzed: female weight, egg mass weight, percentage of hatchability, percentage of reduction in oviposition, percentage of reduction in hatchability, reproductive efficiency and percent control/efficacy of formulations with respect to reproductive parameters. In the experiment I, statistical analysis of the data grouped into 5-days intervals revealed that pour-on application of abamectin (500. mcg/kg) had significantly (p≤. 0.05) reduced engorged female weight, egg mass weight and percent hatchability on days 6-15, 6-20 and 11-20 post-treatment (p. t.) compared to the respective data for detached and pre-selected engorged females in the control group. The abamectin, demonstrated 33.41% of reduction in oviposition, 6.77% in hatchability and abamectin efficacy was of 13.99%. In the experiment II, statistically significant reductions (p≥. 0.05) were observed in animals treated subcutaneous with ivermectin (630. mcg/kg), doramectin (700. mcg/kg) and moxidectin (1000. mcg/kg) relative to the control for days 6-40, 6-48 and 6-40 p. t., respectively. Ivermectin reduced hatchability only on days 16-20 p. t., whereas doramectin significantly reduced (p≤. 0.05) hatchability on days 6-10 and 16-35 p. t. For moxidectin, deleterious effects on hatchability were observed on days 16-35 p. t. The percent reductions in oviposition of engorged female ticks were 46.31%, 62.17% and 61.02% with ivermectin, doramectin and moxidectin treatments, respectively. The percent efficacy of the formulations on the reproductive parameters of engorged female ticks was 21.22% for ivermectin, 36.03% for doramectin and 35.45% for moxidectin. Among the MLs assessed, doramectin and moxidectin had the highest acaricidal efficacies and the most deleterious effects on the reproductive parameters of engorged R. (B.) microplus females. However, future studies will be necessary to assess the extent to which these effects, along with acaricidal activity, can be used to control the ectoparasite in cattle. © 2013 Elsevier Inc..en
dc.description.affiliationCPPAR, Animal Health Research Center Faculdade de Ciências Agrárias e Veterinárias UNESP, Via de acesso Prof. Paulo Donatto Castellani, s/n, CEP 14884-900, Jaboticabal, São Paulo
dc.description.affiliationUnespCPPAR, Animal Health Research Center Faculdade de Ciências Agrárias e Veterinárias UNESP, Via de acesso Prof. Paulo Donatto Castellani, s/n, CEP 14884-900, Jaboticabal, São Paulo
dc.format.extent72-78
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2013.06.003
dc.identifier.citationExperimental Parasitology, v. 135, n. 1, p. 72-78, 2013.
dc.identifier.doi10.1016/j.exppara.2013.06.003
dc.identifier.issn0014-4894
dc.identifier.issn1090-2449
dc.identifier.scopus2-s2.0-84880270762
dc.identifier.urihttp://hdl.handle.net/11449/76402
dc.identifier.wosWOS:000323629200011
dc.language.isoeng
dc.relation.ispartofExperimental Parasitology
dc.relation.ispartofjcr1.821
dc.relation.ispartofsjr0,635
dc.relation.ispartofsjr0,635
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectEngorged femalesen
dc.subjectMacrocyclic lactonesen
dc.subjectReproductive parametersen
dc.subjectRhipicephalus (Boophilus) microplusen
dc.subjectabamectinen
dc.subjectdoramectinen
dc.subjectivermectinen
dc.subjectlactone derivativeen
dc.subjectmacrocyclic compounden
dc.subjectmoxidectinen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectbody weighten
dc.subjectcattle diseaseen
dc.subjectdrug efficacyen
dc.subjectegg layingen
dc.subjectfemaleen
dc.subjectfemale genital systemen
dc.subjecthatchlingen
dc.subjectnonhumanen
dc.subjectpriority journalen
dc.subjecturogenital system parametersen
dc.titleEffects of macrocyclic lactones on the reproductive parameters of engorged Rhipicephalus (Boophilus) microplus females detached from experimentally infested cattleen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4587241487071929[11]

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