Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

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dc.contributor.authorCampos, Mônica S. [UNESP]
dc.contributor.authorSilva, João P. A.
dc.contributor.authorLima, Danilo S.
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorMarques, Mara Rúbia
dc.contributor.authorBiancardi, Manoel F.
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.authorSantos, Fernanda C. A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2019-10-06T16:36:32Z
dc.date.available2019-10-06T16:36:32Z
dc.date.issued2019-06-01
dc.description.abstractChrysin (5,7-dihydroxyflavone) is a bioactive compound found in different fruits, vegetables, honey and propolis. This flavone has been suggested for the treatment of reproductive dysfunction, mainly because of its antioxidant and hormonal properties. However, the effects of this polyphenol on the prostate are still poorly understood. The purpose of this study was to evaluate the effects of short-term chrysin exposure on the ventral male and female prostates of adult gerbils. To evaluate the androgenic potential of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin (50 mg/kg/day, orally) or testosterone cypionate (1 mg/kg/week, subcutaneously) for 3, 7 and 21 days. Prostates were dissected for morphological, stereological and immunohistochemical analyses. Serum levels of testosterone and 17β-estradiol were measured by ELISA. Serum testosterone levels were not increased by chrysin supplementation in males or females. However, only females treated with chrysin for 21 days showed an increase in estradiol levels. Increased androgen receptor immunoreactivity, higher proliferation rates and glandular hyperplasia were observed in male and female prostates for all chrysin treatment times. Additionally, increased oestrogen receptor alpha immunoreactivity was observed in all chrysin-treated females. Although chrysin and testosterone promoted similar morphological changes in the gerbil prostate, chrysin supplementation was less deleterious to prostate health, since it resulted in lower incidence of hyperplasia and an absence of neoplastic foci.en
dc.description.affiliationLaboratory of Microscopy and Microanalysis Department of Biology State University of São Paulo - UNESP
dc.description.affiliationLaboratory of Microscopy Applied to Reproduction Department of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás
dc.description.affiliationLaboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP)
dc.description.affiliationUnespLaboratory of Microscopy and Microanalysis Department of Biology State University of São Paulo - UNESP
dc.description.affiliationUnespLaboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP)
dc.format.extent192-201
dc.identifierhttp://dx.doi.org/10.1111/iep.12317
dc.identifier.citationInternational Journal of Experimental Pathology, v. 100, n. 3, p. 192-201, 2019.
dc.identifier.doi10.1111/iep.12317
dc.identifier.issn1365-2613
dc.identifier.issn0959-9673
dc.identifier.scopus2-s2.0-85067663459
dc.identifier.urihttp://hdl.handle.net/11449/189308
dc.language.isoeng
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectandrogen receptor
dc.subjectflavonoids
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectoestrogen receptor
dc.titleShort-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbilsen
dc.typeArtigo
unesp.author.orcid0000-0002-4476-6046[8]

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Botucatu - CME - Centro de Microscopia Eletrônica
Artigos - Química e Ciências Ambientais - IBILCE