Cytogenetic damage of oral mucosa by consumption of alcohol, tobacco and illicit drugs

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dc.contributor.authorLima, Celina Faig [UNESP]
dc.contributor.authorOliveira, Lidiana Ubina
dc.contributor.authorGuimaraes Cabral, Luiz Antonio [UNESP]
dc.contributor.authorBrandão, Adriana Aigotti Haberbeck [UNESP]
dc.contributor.authorCastillo Salgado, Miguel Angel [UNESP]
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:30Z
dc.date.available2014-05-20T14:04:30Z
dc.date.issued2010-07-01
dc.description.abstractBackground:The aim of the present study was to quantitatively evaluate micronuclei (MN) in the mucosa of users of alcohol, tobacco and illicit drugs in a Brazilian population.Methods:Patients were divided: (i) experimental group - 24 patients users of alcohol, tobacco and illicit drugs from the Center of Psychosocial Care for Alcohol and other Drugs (CAPSad), Sao Jose dos Campos city, and (ii) control group: 24 patients attending the clinics of the Sao Jose dos Campos Dental School FOSJC-UNESP. Criterion for inclusion in the two groups was no visible clinical alteration in the oral mucosa. Exfoliative cytology specimens were obtained from the left side of the border of the tongue. Feulgen staining was used and 600 cells per subject were evaluated by light microscopy.Results:The frequency of MN and micronucleated cells was analysed statistically using the Kruskal-Wallis and Mann-Whitney tests. The incidence of MN was 3.08 +/- 3.20 in the CAPSad group and 2.08 +/- 1.93 in the control group. The frequency of micronucleated cells was 2.38 +/- 2.57 in the CAPSad group and 1.42 +/- 1.25 in the control group.Conclusion:The results showed a higher frequency of MN and micronucleated cells in the CAPSad group, but the difference compared with the control group was not significant.en
dc.description.affiliationSão Paulo State Univ, Postgrad Program Oral Biopathol, UNESP,Dept Biociencias & Diagnost Bucal, Sao Jose Campos Dent Sch,Fac Odontol Sao Jose Cam, BR-12245000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sao Jose Campos Dent Sch, Dept Biosci & Oral Diag, BR-12245000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Postgrad Program Oral Biopathol, UNESP,Dept Biociencias & Diagnost Bucal, Sao Jose Campos Dent Sch,Fac Odontol Sao Jose Cam, BR-12245000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sao Jose Campos Dent Sch, Dept Biosci & Oral Diag, BR-12245000 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 05/60703-9
dc.format.extent441-446
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0714.2010.00887.x
dc.identifier.citationJournal of Oral Pathology & Medicine. Malden: Wiley-blackwell, v. 39, n. 6, p. 441-446, 2010.
dc.identifier.doi10.1111/j.1600-0714.2010.00887.x
dc.identifier.issn0904-2512
dc.identifier.lattes8235700830441386
dc.identifier.lattes9514297710569236
dc.identifier.urihttp://hdl.handle.net/11449/22628
dc.identifier.wosWOS:000279449100001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.relation.ispartofjcr2.237
dc.relation.ispartofsjr0,791
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalcoholen
dc.subjectcytodiagnosisen
dc.subjectmicronucleien
dc.subjectoral mucosaen
dc.subjectsmokingen
dc.titleCytogenetic damage of oral mucosa by consumption of alcohol, tobacco and illicit drugsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes8235700830441386
unesp.author.lattes9514297710569236
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT