Mild diabetes models and their maternal-fetal repercussions

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dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorSinzato, Y. K. [UNESP]
dc.contributor.authorBueno, A. [UNESP]
dc.contributor.authorNetto, A. O. [UNESP]
dc.contributor.authorDallaqua, B. [UNESP]
dc.contributor.authorGallego, F. Q. [UNESP]
dc.contributor.authorIessi, I. L. [UNESP]
dc.contributor.authorCorvino, S. B. [UNESP]
dc.contributor.authorSerrano, R. G. [UNESP]
dc.contributor.authorMarini, G. [UNESP]
dc.contributor.authorPiculo, F. [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:58Z
dc.date.available2014-05-27T11:29:58Z
dc.date.issued2013-07-18
dc.description.abstractThe presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue. © 2013 D. C. Damasceno et al.en
dc.description.affiliationDepartment of Gynecology and Obstetrics Botucatu Medical School Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP
dc.description.affiliationUnespDepartment of Gynecology and Obstetrics Botucatu Medical School Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP
dc.identifierhttp://dx.doi.org/10.1155/2013/473575
dc.identifier.citationJournal of Diabetes Research, v. 2013.
dc.identifier.doi10.1155/2013/473575
dc.identifier.file2-s2.0-84880090248.pdf
dc.identifier.issn2314-6745
dc.identifier.issn2314-6753
dc.identifier.lattes0679387622604743
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.scopus2-s2.0-84880090248
dc.identifier.urihttp://hdl.handle.net/11449/76003
dc.identifier.wosWOS:000321658100001
dc.language.isoeng
dc.relation.ispartofJournal of Diabetes Research
dc.relation.ispartofjcr2.885
dc.relation.ispartofsjr1,116
dc.relation.ispartofsjr1,116
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectstreptozocin
dc.subjectdiabetes mellitus
dc.subjectdiabetogenesis
dc.subjectdisease model
dc.subjectembryo development
dc.subjectexperimental animal
dc.subjectexperimental model
dc.subjecthuman
dc.subjecthyperglycemia
dc.subjectmaternal welfare
dc.subjectmother fetus relationship
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpancreas islet
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectreview
dc.subjectuterus
dc.titleMild diabetes models and their maternal-fetal repercussionsen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/aaa/guidelines/
unesp.author.lattes0679387622604743
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0001-9662-6929[10]
unesp.author.orcid0000-0002-9227-832X[13]
unesp.author.orcid0000-0003-4761-4336[12]
unesp.author.orcid0000-0002-7003-9643[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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