Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus

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dc.contributor.authorBonini-Domingos, Ana Carolina [UNESP]
dc.contributor.authorBonini-Domingos, Claudia Regina [UNESP]
dc.contributor.authorLacida, Edi Carlos [UNESP]
dc.contributor.authorMattos, Cinara de Cássia Brandão de
dc.contributor.authorMattos, Luiz Carlos de
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-04-27T11:55:58Z
dc.date.available2015-04-27T11:55:58Z
dc.date.issued2014
dc.description.abstractThis study was undertaken to assess the frequency of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with type 2 diabetes mellitus. A total of 162 patients with type 2 diabetes and 160 individuals without this disease were analyzed. From the diabetes group, 81 patients with cardiovascular risk (according to American Diabetes Association parameters) were selected to form another subgroup. For polymorphism identification, two polymerase chain reactions were performed: one reaction to identify all genotypes and a second one to confirm the presence of the I allele. The observed genotype frequencies were as follows: diabetes group I/I (19.1%), I/D (52.5%), D/D (28.4%); control group I/I (12.5%), I/D (55.6%), D/D (31.9%); and diabetes with cardiovascular risk group I/I (16.0%), I/ D (59.3%), D/D (24.7%). No statistically significant difference was observed between the allelic and genotypic frequencies in the analyzed groups. Previous studies reported an association between the D allele and type 2 diabetes in Caucasian and East Asian populations. However, in mixed populations, such as those found in Brazil, such an association was not found. This fact does not discard the need for more studies on the frequencies of this polymorphism in the Brazilian population and the associations with risk factors, which can compromise the quality of life of diabetes patientsen
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.format.extent99-104
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S2214024714000574
dc.identifier.citationBiomarkers and Genomic Medicine, v. 6, p. 99-104, 2014.
dc.identifier.doi10.1016/j.bgm.2014.06.001
dc.identifier.issn2214-0247
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.urihttp://hdl.handle.net/11449/122712
dc.language.isoeng
dc.relation.ispartofBiomarkers and Genomic Medicine
dc.relation.ispartofsjr0,206
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectACE polymorphismen
dc.subjectangiotensin converting enzyme polymorphismen
dc.subjectgenetic polymorphismen
dc.subjectI/D polymorphismen
dc.subjecttype 2 diabeten
dc.titleAngiotensin converting enzyme polymorphism in type 2 diabetes mellitusen
dc.typeArtigo
unesp.author.lattes3279428066176719[2]
unesp.author.orcid0000-0002-4603-9467[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologiapt

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