Synthesis and antibacterial activity of new lactone 1,4-dihydroquinoline derivatives

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dc.contributor.authorLaurentiz, Rosangela S. [UNESP]
dc.contributor.authorGomes, Willian P. [UNESP]
dc.contributor.authorPissurno, Ana P. R. [UNESP]
dc.contributor.authorSantos, Fernanda A. [UNESP]
dc.contributor.authorSantos, Vinicius Cristian O.
dc.contributor.authorMartins, Carlos H. G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Franca
dc.date.accessioned2018-12-11T17:18:40Z
dc.date.available2018-12-11T17:18:40Z
dc.date.issued2018-04-01
dc.description.abstractIn this work, a series of lactone 1,4-dihydroquinoline derivatives 4 were efficiently synthesized and characterized by 1H and 13C NMR. The synthesized compounds were evaluated for their in vitro antibacterial activity against the bacterial strains Porphyromonas gingivalis, Prevotella nigrescens, Streptococcus mitis, and Streptococcus sanguinis and against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii. The results revealed that the evaluated compounds were more active against Gram negative bacteria. Compounds 4ba, 4bb, 4bg, 4bi, 4bn, 4ch, and 4ci displayed moderate antibacterial activity against P. gingivalis. 4bi was the most active compound against the three strains of Mycobacterium. Based on structure–activity relationship studies, we observed that the presence of a nitro group on the benzylic ring and a methylenedioxy group on the dihydroquinoline ring enhanced the antibacterial activity of the derivatives.en
dc.description.affiliationDepartment of Physical and Chemistry Universidade Estadual Paulista Júlio de Mesquista Filho (UNESP), Ilha Solteria
dc.description.affiliationResearch Laboratory in Applied Microbiology Universidade de Franca, Franca
dc.description.affiliationUnespDepartment of Physical and Chemistry Universidade Estadual Paulista Júlio de Mesquista Filho (UNESP), Ilha Solteria
dc.format.extent1074-1084
dc.identifierhttp://dx.doi.org/10.1007/s00044-017-2129-x
dc.identifier.citationMedicinal Chemistry Research, v. 27, n. 4, p. 1074-1084, 2018.
dc.identifier.doi10.1007/s00044-017-2129-x
dc.identifier.file2-s2.0-85044229411.pdf
dc.identifier.issn1554-8120
dc.identifier.issn1054-2523
dc.identifier.scopus2-s2.0-85044229411
dc.identifier.urihttp://hdl.handle.net/11449/176043
dc.language.isoeng
dc.relation.ispartofMedicinal Chemistry Research
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectantibacterial activity
dc.subjectAzo-heterocyclic compounds
dc.subjectquinoline derivatives
dc.titleSynthesis and antibacterial activity of new lactone 1,4-dihydroquinoline derivativesen
dc.typeArtigo
unesp.author.orcid0000-0002-5240-4870[1]
unesp.departmentFísica e Química - FEISpt

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Ilha Solteira - FEIS - Faculdade de Engenharia