Is nullity for Glutathione S-transferase genes GSTT1 and GSTM1 protective against leprosy?

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dc.contributor.authorGraca, Carla Renata
dc.contributor.authorCordeiro-Soubhia, Rosa Maria
dc.contributor.authorTonelli-Nardi, Susilene Maria
dc.contributor.authorBelini Junior, Edis [UNESP]
dc.contributor.authorBonini-Domingos, Claudia Regina [UNESP]
dc.contributor.authorGauch, Camila Ravazzi
dc.contributor.authorDa Silva Da Rocha, Elisabeth Martins
dc.contributor.authorPaschoal, Vania Delarco
dc.contributor.authorKouyoumdjian, Joao Aris
dc.contributor.authorDe Souza Baptista, Andrea Regina
dc.contributor.institutionFac Med Sao Jose do Rio Preto FAMERP
dc.contributor.institutionInst Lauro de Souza Lima
dc.contributor.institutionAdolfo Lutz Inst
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.date.accessioned2018-11-26T16:56:23Z
dc.date.available2018-11-26T16:56:23Z
dc.date.issued2016-06-01
dc.description.abstractIntroduction: Leprosy is a slow and progressive infectious disease caused by Mycobacterium leprae. The generation of free radicals called reactive oxygen species (ROS), which promote destruction of the bacillus within macrophages, is an effective defence mechanism developed by the host. In parallel, the glutathione S-transferase (GST) multifamily of enzymes constitutes an important antioxidant system for ROS detoxification and protection against toxicity. Therefore, GST null genotype individuals could reduce the detoxification of ROS, increasing host effectiveness for M. leprae destruction. Objectives: To evaluate polymorphisms in the GSTT1 and GSTM1 genes as human leprosy susceptibility modulators. Methods: GSTT and GSTM1 polymorphisms were genotyped by a multiplex polymerase chain reaction (PCR) in 218 leprosy patients and 244 non-leprosy subjects (control group). Results: The occurrence of the GSTT1/GSTM1 null genotype was significantly higher among control subjects than amongst leprosy patients (P = 0.01). The GSTT positive genotype frequency was significantly increased in leprosy patients when compared with control subjects (P = 0.01). Conclusions: The results suggest that GSTT1/M1 nullity may play an important role in leprosy pathogenesis. Significance: Despite these findings, further studies will be necessary to ascertain the exact role of these genes in leprosy and to design any future prevention measures or contributions to drug therapy.en
dc.description.affiliationFac Med Sao Jose do Rio Preto FAMERP, Sao Paulo, Brazil
dc.description.affiliationInst Lauro de Souza Lima, Bauru, SP, Brazil
dc.description.affiliationAdolfo Lutz Inst, Ctr Lab Reg, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estado Sao Paulo UNESP, Dept Biol, Lab Hemoglobinas & Genet Doencas Hematol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, Niteroi, RJ, Brazil
dc.description.affiliationUnespUniv Estado Sao Paulo UNESP, Dept Biol, Lab Hemoglobinas & Genet Doencas Hematol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipBAP-FAMERP
dc.description.sponsorshipFundacao Paulista Contra a Hanseniase
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdBAP-FAMERP: 022/2010
dc.description.sponsorshipIdFundacao Paulista Contra a Hanseniase: 123/2008
dc.description.sponsorshipIdFundacao Paulista Contra a Hanseniase: 136/2010
dc.description.sponsorshipIdFAPESP: 2008/11626-0
dc.format.extent232-238
dc.identifier.citationLeprosy Review. Colchester: Lepra, v. 87, n. 2, p. 232-238, 2016.
dc.identifier.issn0305-7518
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.urihttp://hdl.handle.net/11449/161826
dc.identifier.wosWOS:000381543000010
dc.language.isoeng
dc.publisherLepra
dc.relation.ispartofLeprosy Review
dc.relation.ispartofsjr0,563
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectGlutathione S-transferase
dc.subjectLeprosy
dc.subjectReactive Oxygen Species
dc.subjectMycobacterium leprae
dc.titleIs nullity for Glutathione S-transferase genes GSTT1 and GSTM1 protective against leprosy?en
dc.typeArtigo
dcterms.rightsHolderLepra
unesp.author.lattes3279428066176719[5]
unesp.author.orcid0000-0001-6478-8173[4]
unesp.author.orcid0000-0002-4603-9467[5]

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