Kinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venom

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dc.contributor.authorSangiorgio, F. [UNESP]
dc.contributor.authorSakate, M. [UNESP]
dc.contributor.authorNogueira, R. M. B.
dc.contributor.authorAraújo Junior, J. P. [UNESP]
dc.contributor.authorChavez-Olortegui, C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2014-05-20T13:51:12Z
dc.date.available2014-05-20T13:51:12Z
dc.date.issued2008-01-01
dc.description.abstractThis work evaluated the clinical and therapeutic aspects as well as serum levels of venom and antivenom IgG by enzyme-linked immunosorbent assay (ELISA) in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into four groups of seven animals each, Group I: only venom; Group II, venom + 50 ml of anti-bothropic-crotalic serum (50mg) + fluid therapy; Group III, venom + 50 ml of anti-bothropic-crotalic serum + fluid therapy + urine alkalination; Group IV, 50 ml of anti-bothropic-crotalic serum. The lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and subcutaneously inoculated at the dose of 1mg/kg body weight. The dogs presented clinical signs of local pain, weakness, mandibular ptosis, mydriasis, emesis and salivation. The venom levels detected by ELISA ranged from 0 to 90ng/ml, according to the severity of the clinical signs. Serum antivenom ranged from 0 to 3ug/ml and was detected for up to 138h after treatment. ELISA results showed the effectiveness of the serum therapy for the venom neutralization.en
dc.description.affiliationSão Paulo State University School of Veterinary Medicine and Animal Husbrandy Department of Small Animal Medical Clinic and Toxicology
dc.description.affiliationUniversity of Western São Paulo Department of Small Animal Medical Clinic
dc.description.affiliationUNESP Botucatu Institute of Biosciences Department of Microbiology and Immunology
dc.description.affiliationFederal University of Minas Gerais Institute of Biological Sciences Department of Biochemistry and Immunology
dc.description.affiliationUnespSão Paulo State University School of Veterinary Medicine and Animal Husbrandy Department of Small Animal Medical Clinic and Toxicology
dc.description.affiliationUnespUNESP Botucatu Institute of Biosciences Department of Microbiology and Immunology
dc.format.extent100-112
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000100008
dc.identifier.citationJournal of Venomous Animals and Toxins including Tropical Diseases. Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 14, n. 1, p. 100-112, 2008.
dc.identifier.doi10.1590/S1678-91992008000100008
dc.identifier.fileS1678-91992008000100008.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992008000100008
dc.identifier.urihttp://hdl.handle.net/11449/18279
dc.identifier.wosWOS:000254511600008
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectCrotalus durissus terrificusen
dc.subjectdogsen
dc.subjectclinical signsen
dc.subjectELISAen
dc.titleKinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venomen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
dcterms.rightsHolderCevap-unesp
unesp.author.orcid0000-0002-9153-1485[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB