Tissue distribution of lycopene in ferrets and rats after lycopene supplementation

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dc.contributor.authorFerreira, Ana Lúcia dos Anjos [UNESP]
dc.contributor.authorYeum, Kyung-Jin
dc.contributor.authorLiu, Chun
dc.contributor.authorSmith, Donald
dc.contributor.authorKrinsky, Norman I.
dc.contributor.authorWang, Xiang-Dong
dc.contributor.authorRussell, Robert M.
dc.contributor.institutionTufts University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:54Z
dc.date.available2014-05-27T11:19:54Z
dc.date.issued2000-05-11
dc.description.abstractTo determine lycopene uptake and tissue distribution in ferrets (Mustela putorius furo) and F344 rats, we supplemented orally 4.6 mg/(kg body wt-d) lycopene in a tomato oleoresin-com oil mixture (experimental groups). After 9 wk of supplementation, the animals were killed and blood and organs were collected. Plasma and tissue carotenoids were extracted and measured using HPLC. Mean concentrations of lycopene (nmol/kg wet tissue) in saponified tissues of ferrets were as follows: liver 933, intestine 73, prostate 12.7 and stomach 9.3. Levels of lycopene (nmol/kg wet tissue) in saponified tissue of rats were as follows: liver 14213, intestine 3125, stomach 78.6, prostate 24 and testis 3.9. When these organs were extracted without saponification, the lycopene levels were lower, except for rat testis. All-translycopene was the predominant isomer found in tomato oleoresin and in the majority of rat tissues, whereas cislycopenes were predominant in rat prostate and plasma. This pattern was reversed in ferrets. The results show the following: 1) lycopene from tomato oleoresin is absorbed and stored primarily in the liver of both animals; 2) saponification generally improves the extraction of lycopene from most tissues of both animals; 3) cis-lycopene and all- translycopene are the predominant isomers in ferret and rat tissues, respectively; and 4) rats absorb lycopene more effectively than ferrets.en
dc.description.affiliationJean Mayer, U.S. Dept. of Agric. Hum. Nutr. Research Center on Aging Tufts University, Boston, MA 02111
dc.description.affiliationFaculdade de Medicina UNESP, CP 584, Botucatu, SP, 18618-970
dc.description.affiliationUnespFaculdade de Medicina UNESP, CP 584, Botucatu, SP, 18618-970
dc.format.extent1256-1260
dc.identifierhttp://jn.nutrition.org/content/130/5/1256.long
dc.identifier.citationJournal of Nutrition, v. 130, n. 5, p. 1256-1260, 2000.
dc.identifier.issn0022-3166
dc.identifier.lattes2940051650846541
dc.identifier.scopus2-s2.0-0034012188
dc.identifier.urihttp://hdl.handle.net/11449/66157
dc.identifier.wosWOS:000086873200028
dc.language.isoeng
dc.relation.ispartofJournal of Nutrition
dc.relation.ispartofjcr4.398
dc.relation.ispartofsjr2,191
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectFerrets
dc.subjectLycopene
dc.subjectProstate
dc.subjectRats
dc.subjectTestis
dc.subjectcarotenoid
dc.subjectcorn oil
dc.subjectlycopene
dc.subjectresin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcis isomer
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectextraction
dc.subjectferret
dc.subjecthigh performance liquid chromatography
dc.subjectintestine
dc.subjectliver level
dc.subjectmale
dc.subjectnonhuman
dc.subjectprostate
dc.subjectrat
dc.subjectstomach
dc.subjecttestis
dc.subjecttissue distribution
dc.subjecttissue level
dc.subjecttomato
dc.subjecttrans isomer
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCarotenoids
dc.subjectChromatography, High Pressure Liquid
dc.subjectDietary Supplements
dc.subjectIntestinal Absorption
dc.subjectMale
dc.subjectRats, Inbred F344
dc.subjectSpecies Specificity
dc.subjectTissue Distribution
dc.subjectAnimalia
dc.subjectLycopersicon esculentum
dc.subjectMustela
dc.subjectMustela putorius furo
dc.subjectZea mays
dc.titleTissue distribution of lycopene in ferrets and rats after lycopene supplementationen
dc.typeArtigo
dcterms.licensehttp://www.ajcn.org/site/misc/Authors%27_Agreement_Form.pdf
unesp.author.lattes2940051650846541[1]
unesp.author.orcid0000-0002-5267-1127[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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