An Unprecedented Neolignan Skeleton from Chimarrhis turbinata
dc.contributor.author | Cardoso, Carmen L. | |
dc.contributor.author | Castro-Gamboa, Ian [UNESP] | |
dc.contributor.author | Bergamini, Giovana M. | |
dc.contributor.author | Cavalheiro, Alberto José [UNESP] | |
dc.contributor.author | Silva, Dulce Helena Siqueira [UNESP] | |
dc.contributor.author | Lopes, Márcia Nasser [UNESP] | |
dc.contributor.author | Araújo, Angela Regina [UNESP] | |
dc.contributor.author | Furlan, Maysa [UNESP] | |
dc.contributor.author | Verli, Hugo | |
dc.contributor.author | Bolzani, Vanderlan da Silva [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.date.accessioned | 2014-05-20T14:20:08Z | |
dc.date.available | 2014-05-20T14:20:08Z | |
dc.date.issued | 2011-03-01 | |
dc.description.abstract | A lignan with a new skeleton named chimarrhinin (1) was isolated from an extract of the leaves of Chimarrhis turbinata, a Rubiaceae plant species. (13)C NMR spectrometric techniques including 1D and 2D experiments and HRESIMS provided unequivocal structural confirmation of this new C(6).C(3) skeleton type. The relative configuration of 1 was established by 2D (1)H-H analysis and J couplings, while its conformation was evaluated through molecular modeling using the RM1 semiempirical method, with the aid of coupling constants obtained by NMR analysis. The antioxidant activity of the new derivative 1 and two known and previously isolated phenolic derivatives (2 and 3) was investigated. An IC(50) value of 7.50 +/- 0.5 mu mol L(-1) was obtained for the new derivative 1, while 2 and 3 showed IC(50) values of 18.60 +/- 0.4 and 18.50 +/- 0.6 mu mol, respectively. | en |
dc.description.affiliation | São Paulo State Univ, Inst Chem, UNESP, BR-14800900 Araraquara, SP, Brazil | |
dc.description.affiliation | Univ São Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 São Paulo, Brazil | |
dc.description.affiliation | Universidade Federal do Rio Grande do Sul (UFRGS), Fac Pharm, UFRGS, BR-90610000 Porto Alegre, RS, Brazil | |
dc.description.affiliation | Universidade Federal do Rio Grande do Sul (UFRGS), Ctr Biotechnol, UFRGS, BR-90610000 Porto Alegre, RS, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, Inst Chem, UNESP, BR-14800900 Araraquara, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | FAPESP: 03/02176-7 | |
dc.description.sponsorshipId | CNPq: 420015/2005-1 | |
dc.description.sponsorshipId | CNPq: 472174/2007-0 | |
dc.format.extent | 487-491 | |
dc.identifier | http://dx.doi.org/10.1021/np1007476 | |
dc.identifier.citation | Journal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 3, p. 487-491, 2011. | |
dc.identifier.doi | 10.1021/np1007476 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.lattes | 2518006820764120 | |
dc.identifier.lattes | 4702004904231248 | |
dc.identifier.lattes | 3310170899693944 | |
dc.identifier.lattes | 0037579054083160 | |
dc.identifier.lattes | 1308042794786872 | |
dc.identifier.lattes | 4484083685251673 | |
dc.identifier.orcid | 0000-0001-7616-9652 | |
dc.identifier.orcid | 0000-0002-1516-7765 | |
dc.identifier.uri | http://hdl.handle.net/11449/26048 | |
dc.identifier.wos | WOS:000288691800029 | |
dc.language.iso | eng | |
dc.publisher | Amer Chemical Soc | |
dc.relation.ispartof | Journal of Natural Products | |
dc.relation.ispartofjcr | 3.885 | |
dc.relation.ispartofsjr | 1,368 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | An Unprecedented Neolignan Skeleton from Chimarrhis turbinata | en |
dc.type | Artigo | |
dcterms.license | http://pubs.acs.org/page/policy/nih/index.html | |
dcterms.rightsHolder | Amer Chemical Soc | |
unesp.author.lattes | 2518006820764120[4] | |
unesp.author.lattes | 4702004904231248[5] | |
unesp.author.lattes | 3310170899693944 | |
unesp.author.lattes | 0037579054083160[7] | |
unesp.author.lattes | 1308042794786872 | |
unesp.author.lattes | 4484083685251673 | |
unesp.author.orcid | 0000-0001-7616-9652[7] | |
unesp.author.orcid | 0000-0002-1516-7765[5] | |
unesp.author.orcid | 0000-0001-8214-9957[4] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Química, Araraquara | pt |
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