Glycol thermal synthesis of the 45B5 bioactive borate glass: Structural, physical, and apatite mineralization in vitro

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dc.contributor.authordos Santos, Verônica Ribeiro
dc.contributor.authorCampos, Tiago Moreira Bastos
dc.contributor.authorThim, Gilmar Patrocínio
dc.contributor.authorBorges, Alexandre Luiz Souto [UNESP]
dc.contributor.authorde Sousa Trichês, Eliandra
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAeronautic Technological Institute
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T15:34:47Z
dc.date.available2023-07-29T15:34:47Z
dc.date.issued2023-04-01
dc.description.abstractThis work was performed aiming to develop a new and straightforward route for bioactive glasses obtention with minimal equipment and explore the structural, physical, and bioactivity properties of the resulting glass and its glass ceramics. Herein, the synthesis of the borate bioactive glass in the 45B5 composition (46.1 B2O3 – 26.9 CaO – 24.4 NaO – 2.6 P2O5, mol%) by the glycol thermal method was proposed; an original chemical route for bioactive glass obtention based on transesterification reaction between the precursors with a glycol. The suggested mechanism for the borate network formation was proven accurate, revealing a vitreous structure formed by ring-type metaborate structural units with a lamellar morphology upon calcination. Glass-ceramics obtained at 500 (45B5-500) and 700 °C (45B5-700) indicate the oxides were effectively incorporated into the network by crystallization of Ca–Na–B, Ca–B, and Na–B phases. The in vitro apatite mineralization assay performed on the glass and glass-ceramics revealed their great solubility and conversion rate into hydroxyapatite (HA, Ca5(PO4)3(OH)), which is taken as an indication of bioactivity. Besides HA, however, calcium carbonate species were identified at the early stages of mineralization for 45B5 and 45B5-500, suggesting the 45B5-700 glass-ceramic has a higher ability to form apatite as the majority of Ca2+ are directed to precipitate into hydroxyapatite. Overall, the 45B5 glass and glass-ceramics demonstrated their great bioactivity, having high application potential in soft tissue engineering on wound healing materials and devices, as incorporation in hydrogels and nanofibers. Furthermore, the glycol thermal method generated new perspectives for the synthesis of a broad range of bioactive glasses compositions and their application in tissue engineering.en
dc.description.affiliationUniversidade Federal de São Paulo Instituto de Ciência e Tecnologia, 330 Talim St
dc.description.affiliationAeronautic Technological Institute, 50, Marechal Eduardo Gomes Square
dc.description.affiliationSao Paulo State University Institute of Science and Technology Department of Dental Materials and Prosthodontics, 777, Engenheiro Francisco José Longo Avenue
dc.description.affiliationUnespSao Paulo State University Institute of Science and Technology Department of Dental Materials and Prosthodontics, 777, Engenheiro Francisco José Longo Avenue
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipInternational Trade Administration
dc.description.sponsorshipUniversidade Federal de São Paulo
dc.format.extent11236-11248
dc.identifierhttp://dx.doi.org/10.1016/j.ceramint.2022.11.321
dc.identifier.citationCeramics International, v. 49, n. 7, p. 11236-11248, 2023.
dc.identifier.doi10.1016/j.ceramint.2022.11.321
dc.identifier.issn0272-8842
dc.identifier.scopus2-s2.0-85143171090
dc.identifier.urihttp://hdl.handle.net/11449/249428
dc.language.isoeng
dc.relation.ispartofCeramics International
dc.sourceScopus
dc.subjectBiomedical applications
dc.subjectGlass
dc.subjectGlass-ceramics
dc.subjectPowders: chemical preparation
dc.titleGlycol thermal synthesis of the 45B5 bioactive borate glass: Structural, physical, and apatite mineralization in vitroen
dc.typeArtigo
unesp.author.orcid0000-0002-9487-3114[1]
unesp.author.orcid0000-0002-9923-8611[5]

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