Biomechanical and Microstructural Benefits of Physical Exercise Associated With Risedronate in Bones of Ovariectomized Rats

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dc.contributor.authorShimano, Roberta Carminati
dc.contributor.authorMacedo, Ana Paula
dc.contributor.authorFalcai, Mauricio Jose
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorShimano, Antonio Carlos
dc.contributor.authorMardegan Issa, Joao Paulo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:07:04Z
dc.date.available2014-12-03T13:07:04Z
dc.date.issued2014-06-01
dc.description.abstractSeveral treatments have been developed aiming the prevention of bone loss. There are discussions about the best prophylactic and therapeutic procedures for osteoporosis. This study evaluated the effects of physical exercise associated with risedronate as a prophylactic and therapeutic procedure in osteopenic bones of rats submitted to ovariectomy. We used 48 Wistar rats divided into: ovariectomized or subjected to sham surgery. Ovariectomized rats were divided into the following sub-groups: OVX, 12 weeks sedentary; OVX-EX, treadmill training for 12 weeks; OVX-RA, 12 weeks with risedronate administration; and OVX-EX-RA, 12 weeks with risedronate administration and treadmill training. Rats subjected to sham surgery were divided into the following sub-groups: SH, 12 weeks sedentary; SH-EX, treadmill training for 12 weeks; SH-RA, 12 weeks with risedronate administration; and SH-EX-RA, 12 weeks with risedronate administration and training on the treadmill. The effectiveness of the treatment was evaluated in tibias using biomechanical, radiological, histomorphometric, and immunohistochemical analyses. Data were analyzed by statistical tests, with significance level of P < 0.05. Results of mechanical tests showed that the SH-RA group had lower values compared with OVX-RA group; densitometry showed no significant differences; according to histomorphometric methods, OVX group presented lower results than the SH-EX, OVX-RA, SH-EX-RA, and OVX-EX-RA groups, and SH-EX-RA and OVX-EX-RA groups showed values higher than SH-RA, SH, and OVX-EX groups. The SH-EX-RA and OVX-EX-RA groups had decreased immunostaining for tartrate-resistant acid phosphatase and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin immunostaining. In this experimental model, it was concluded that the physical training associated with use of risedronate exerted positive effects on biomechanical and microstructural properties in bones of ovariectomized rats. (C) 2014 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Biomech Med & Locomotor Apparat Rehabil, Sao Paulo, Brazil
dc.description.affiliationSao Paulo State Univ, Fac Dent, Dept Basic Sci Histol & Embryol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Dent, Dept Morphol Physiol & Basic Pathol, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Fac Dent, Dept Basic Sci Histol & Embryol, Sao Paulo, Brazil
dc.format.extent431-438
dc.identifierhttp://dx.doi.org/10.1002/jemt.22363
dc.identifier.citationMicroscopy Research And Technique. Hoboken: Wiley-blackwell, v. 77, n. 6, p. 431-438, 2014.
dc.identifier.doi10.1002/jemt.22363
dc.identifier.issn1059-910X
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.urihttp://hdl.handle.net/11449/111221
dc.identifier.wosWOS:000337240200005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.ispartofjcr1.087
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbone diseasesen
dc.subjectmetabolicen
dc.subjectmedicineen
dc.subjectmicroscopyen
dc.subjectphysical exerciseen
dc.titleBiomechanical and Microstructural Benefits of Physical Exercise Associated With Risedronate in Bones of Ovariectomized Ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes4408095517346846[4]
unesp.author.orcid0000-0003-4859-0583[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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