Case study of two post vaccination SARS-CoV-2 infections with P1 variants in coronavac vaccinees in Brazil

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dc.contributor.authorEstofolete, Cassia F.
dc.contributor.authorBanho, Cecilia A.
dc.contributor.authorCampos, Guilherme R.F.
dc.contributor.authorMarques, Beatriz C.
dc.contributor.authorSacchetto, Livia
dc.contributor.authorUllmann, Leila S. [UNESP]
dc.contributor.authorPossebon, Fabio S. [UNESP]
dc.contributor.authorMachado, Luana F.
dc.contributor.authorSyrio, Juliana D.
dc.contributor.authorAraújo Junior, João P. [UNESP]
dc.contributor.authorBittar, Cintia [UNESP]
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorLobo, Suzana M.A.
dc.contributor.authorFerreira, Helena Lage
dc.contributor.authorVasilakis, Nikos
dc.contributor.authorNogueira, Mauricio L.
dc.contributor.institutionMedicine School of São José do Rio Preto (FAMERP)
dc.contributor.institutionHospital de Base
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Texas Medical Branch
dc.date.accessioned2022-05-01T06:02:16Z
dc.date.available2022-05-01T06:02:16Z
dc.date.issued2021-07-01
dc.description.abstractThe rapid development of efficacious and safe vaccines against coronavirus disease 2019 (COVID-19) has been instrumental in mitigating the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the emergence of SARS-CoV-2 variants raised concerns on the efficacy of these vaccines. Herein, we report two cases of breakthrough infections with the P1 variant in patients vaccinated with CoronaVac, which is one of the two vaccines authorized for emergency use in the Brazilian immunization program. Our observations suggest that the vaccine reduced the severity of the disease and highlight the potential risk of illness following vaccination and subsequent infection with the P1 variant as well as for continued efforts to prevent and diagnose infection in vaccinated persons.en
dc.description.affiliationLaboratório de Pesquisas em Virologia (LPV) Medicine School of São José do Rio Preto (FAMERP)
dc.description.affiliationHospital de Base
dc.description.affiliationBiotecnology Institute São Paulo State University (UNESP)
dc.description.affiliationIntitute of Biosciences Languages and Exact Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Veterinary Medicine FZEA-USP University of São Paulo (USP)
dc.description.affiliationDepartment of Pathology University of Texas Medical Branch, 301 University Blvd
dc.description.affiliationSealy Center for Vector-Borne and Zoonotic Diseases University of Texas Medical Branch, 301 University Blvd
dc.description.affiliationCenter for Biodefense and Emerging Infectious Diseases University of Texas Medical Branch, 301 University Blvd
dc.description.affiliationCenter for Tropical Diseases University of Texas Medical Branch, 301 University Blvd
dc.description.affiliationInstitute for Human Infection and Immunity University of Texas Medical Branch, 301 University Blvd
dc.description.affiliationUnespBiotecnology Institute São Paulo State University (UNESP)
dc.description.affiliationUnespIntitute of Biosciences Languages and Exact Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/v13071237
dc.identifier.citationViruses, v. 13, n. 7, 2021.
dc.identifier.doi10.3390/v13071237
dc.identifier.issn1999-4915
dc.identifier.scopus2-s2.0-85109565185
dc.identifier.urihttp://hdl.handle.net/11449/233252
dc.language.isoeng
dc.relation.ispartofViruses
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectVaccine
dc.titleCase study of two post vaccination SARS-CoV-2 infections with P1 variants in coronavac vaccinees in Brazilen
dc.typeArtigo
unesp.author.orcid0000-0001-7324-1591 0000-0001-7324-1591[1]
unesp.author.orcid0000-0001-5090-1534[2]
unesp.author.orcid0000-0003-1118-8486[3]
unesp.author.orcid0000-0001-9716-6899[5]
unesp.author.orcid0000-0002-0118-6164[7]
unesp.author.orcid0000-0002-9153-1485[10]
unesp.author.orcid0000-0002-2048-4589[11]
unesp.author.orcid0000-0003-2726-2441[13]
unesp.author.orcid0000-0002-3261-3712[14]
unesp.author.orcid0000-0002-0708-3289 0000-0002-0708-3289 0000-0002-0708-3289 0000-0002-0708-3289 0000-0002-0708-3289[15]

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