Can maternal exposure to tamoxifen compromise sperm and behavioural parameters of male rat offspring?

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dc.contributor.authorde Matos Manoel, Beatriz
dc.contributor.authorda Silva Moreira, Suyane [UNESP]
dc.contributor.authorZampieri, Gabriela Morelli [UNESP]
dc.contributor.authorMachado Pinheiro, Luísa [UNESP]
dc.contributor.authorJorge, Bárbara Campos [UNESP]
dc.contributor.authorCasali Reis, Ana Carolina [UNESP]
dc.contributor.authorLeite Kassuya, Cândida Aparecida
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionUniversidade Federal da Grande Dourados – UFGD
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:38:44Z
dc.date.available2022-04-29T08:38:44Z
dc.date.issued2022-03-01
dc.description.abstractTamoxifen, a selective non-steroidal estrogen receptor modulator, is the standard adjuvant endocrine treatment for breast cancer. Since information on the risk of using tamoxifen during pregnancy is still scarce, this study evaluated whether the in utero and lactational treatment with this drug could compromise reproductive and behavioural parameters in male offspring. Pregnant Wistar rats were exposed to three doses of tamoxifen (0.12; 0.6; 3 μg/kg), by gavage, from gestational day 15 to lactational day 20. Tamoxifen exposure did not alter the anogenital distance in the male offspring; however, there was a significant increase in the body weight in the 0.12 μg/kg dose and a decrease in the 0.6 μg/kg dose. The male offspring treated with the highest dose exhibited a delay in the onset of puberty, evidenced by an increase in the age of preputial separation. Regarding sperm parameters, there was an increase in the sperm count in the cauda epididymis in the intermediate and highest dose groups, in addition to an increase in the number of static sperm and a decrease in the progressive sperm in the same groups. Moreover, an increase in the number of hyperplasia of the epithelial clear cells was observed in the epididymis. In conclusion, the present study demonstrated that maternal exposure to tamoxifen compromised the installation of puberty of the male offspring and the maturation of the epididymis, affecting sperm storage and motility in the adult life.en
dc.description.affiliationFaculty of Health Sciences Universidade Federal da Grande Dourados – UFGD
dc.description.affiliationDepartamet of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP
dc.description.affiliationCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.description.affiliationUnespDepartamet of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP
dc.description.affiliationUnespCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)
dc.format.extent1-9
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2021.12.010
dc.identifier.citationReproductive Toxicology, v. 108, p. 1-9.
dc.identifier.doi10.1016/j.reprotox.2021.12.010
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-85123166366
dc.identifier.urihttp://hdl.handle.net/11449/230252
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.sourceScopus
dc.subjectbrain sexual differentiation
dc.subjectepididymis
dc.subjectreproductive parameters
dc.subjectSelective estrogen receptor modulator
dc.subjectsexual development
dc.titleCan maternal exposure to tamoxifen compromise sperm and behavioural parameters of male rat offspring?en
dc.typeArtigo
unesp.author.orcid0000-0002-3281-6085[1]
unesp.author.orcid0000-0003-1890-2558[4]
unesp.author.orcid0000-0001-8754-4876[5]
unesp.author.orcid0000-0002-8998-9219[7]
unesp.author.orcid0000-0002-2373-9399 0000-0002-2373-9399[8]

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Botucatu - CEATOX - Centro de Assistência Toxicológica