Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos

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dc.contributor.authorPereira, Danyella Silva
dc.contributor.authorKoike, Bruna Del Vechio
dc.contributor.authorRibeiro, Amanda de Oliveira [UNESP]
dc.contributor.authorUmemura, Guilherme Silva
dc.contributor.authorTufik, Sergio
dc.contributor.authorNeto, Mario Pedrazzoli
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:30:08Z
dc.date.available2014-05-27T11:30:08Z
dc.date.issued2013-08-08
dc.description.abstractHIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis.en
dc.description.affiliationDepartment of Psychobiology Universidade Federal de São Paulo, São Paulo
dc.description.affiliationDepartment of Genetics Universidade Estadual de São Paulo, Botucatu
dc.description.affiliationSchool of Arts, Science and Humanities Universidade de São Paulo, São Paulo
dc.description.affiliationUnespDepartment of Genetics Universidade Estadual de São Paulo, Botucatu
dc.format.extent66-71
dc.identifierhttp://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf
dc.identifier.citationSleep Science, v. 6, n. 2, p. 66-71, 2013.
dc.identifier.file2-s2.0-84881050964.pdf
dc.identifier.issn1984-0659
dc.identifier.issn1984-0063
dc.identifier.scopus2-s2.0-84881050964
dc.identifier.urihttp://hdl.handle.net/11449/76243
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofSleep Science
dc.relation.ispartofsjr0,570
dc.relation.ispartofsjr0,570
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCircadian rhythm
dc.subjectGenetics behavorial
dc.subjectMelatonin
dc.subjectPolymorphism genetic
dc.titleRastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianospt
dc.title.alternativeScreening for polymorphisms in the HIOMT gene and associations with circadian phenotypesen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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