Sympathetic mediation of salivation induced by intracerebroventricular pilocarpine in rats

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dc.contributor.authorCecanho, R.
dc.contributor.authorAnaya, M.
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorDe Luca, L. A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:43Z
dc.date.available2014-05-20T13:45:43Z
dc.date.issued1999-04-16
dc.description.abstractCentral cholinergic activation by pilocarpine induces salivation dependent on the integrity of forebrain areas. The present work investigates the autonomic mediation of this salivation. Pilocarpine (500 nmol/rat) was injected into the lateral ventricle (LV) of tribromoethanol-anesthetized adult male rats. Preweighed cotton balls were inserted into the oral cavity and weighed again 7 min later. ol-adrenoceptor antagonists (3-50 mu mol/kg) prazosin (alpha(1)), yohimbine (alpha(2)) or propranolol (beta) injected intraperitoneally (i.p.) produced, 80%, 20% and 0% inhibition respectively of the LV pilocarpine-induced salivation. Intracerebroventricular injections (160 nmol) of the antagonists did not alter the effects of pilocarpine injected into the LV. Bilateral section of chorda tympani nerve or bilateral sympathetic cervical ganglionectomy produced 0% and 40% inhibition of pilocarpine-induced salivation, respectively. Ganglionectomy did not alter salivation induced by i.p, injection of pilocarpine (4 mu mol/kg). The results indicate that there is a large sympathetic contribution to the salivation induced by central cholinergic activation. (C) 1999 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationPaulista State Univ, UNESP, Sch Odontol, Dept Physiol Sci, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespPaulista State Univ, UNESP, Sch Odontol, Dept Physiol Sci, BR-14801903 Araraquara, SP, Brazil
dc.format.extent9-14
dc.identifierhttp://dx.doi.org/10.1016/S0165-1838(99)00002-8
dc.identifier.citationJournal of the Autonomic Nervous System. Amsterdam: Elsevier B.V., v. 76, n. 1, p. 9-14, 1999.
dc.identifier.doi10.1016/S0165-1838(99)00002-8
dc.identifier.issn0165-1838
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16100
dc.identifier.wosWOS:000079858800002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of the Autonomic Nervous System
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcholinergic receptorspt
dc.subjectadrenoceptorspt
dc.subjectcervical ganglionpt
dc.subjectchorda tympanipt
dc.subjectsalivary glandspt
dc.subjectlateral ventriclept
dc.subjectsalivapt
dc.titleSympathetic mediation of salivation induced by intracerebroventricular pilocarpine in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-8270-2652[5]
unesp.author.orcid0000-0003-1167-4441[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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