Effect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

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dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:17Z
dc.date.available2014-05-20T13:35:17Z
dc.date.issued2008-02-28
dc.description.abstractEthnopharmacological relevance: Bauhinia forficata Link, commonly known as paw-of-cow, is widely used in Brazilian folk medicine for the treatment of diabetes.Aim of this study: To evaluate the effect of Bauhinia forficata treatment on maternal-fetal outcome and antioxidant systems of streptozotocin-induced diabetic rats.Materials and methods: Virgin female Wistar rats were injected with 40 mg/kg streptozotocin before mating. Oral administration of an aqueous extract of Bauhinia forficata leaves was given to non-diabetic and diabetic pregnant rats at increasing doses: 500 mg/kg from 0 to 4th day of pregnancy, 600 mg/kg from 5th to 14th day and 1000 mg/kg from 15th to 20th day. At day 21 of pregnancy the rats were anaesthetized with ether and a maternal blood sample was collected for the determination superoxide dismutase (SOD) and reduced glutathione (GSH). The gravid uterus was weighed with its contents and fetuses were analyzed.Results and conclusion: The data showed that the diabetic dams presented an increased glycemic level, resorption, placental weight, placental index, and fetal anomalies, and reduced GSH and SOD determinations, live fetuses, maternal weight gain, gravid uterine weight, and fetal weight. It was also verified that Bauhinia forficata treatment had no hypoglycemic effect, did not improve maternal outcomes in diabetic rats, but it contributed to maintain GSH concentration similarly to non-diabetic groups, suggesting relation with the decreased incidence of visceral anomalies. (C) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Fac Med, Dept Obstet & Ginecol, Lab Pesquisa Expt Ginecol & Obstet, BR-18610000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Inst Biociencias Botucatu, Dept Morfol, BR-18610000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Inst Biociencias Botucatu, Dept Bioestat, BR-18610000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Med, Dept Obstet & Ginecol, Lab Pesquisa Expt Ginecol & Obstet, BR-18610000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias Botucatu, Dept Morfol, BR-18610000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias Botucatu, Dept Bioestat, BR-18610000 Botucatu, SP, Brazil
dc.format.extent131-137
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2007.11.013
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 116, n. 1, p. 131-137, 2008.
dc.identifier.doi10.1016/j.jep.2007.11.013
dc.identifier.issn0378-8741
dc.identifier.lattes0679387622604743
dc.identifier.lattes6758680388835078
dc.identifier.lattes8727897080522289
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/12128
dc.identifier.wosWOS:000253398000020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBauhinia forficataen
dc.subjectdiabetesen
dc.subjectpregnancyen
dc.subjectreproductive outcomeen
dc.subjectanomalyen
dc.subjectleguminosaeen
dc.titleEffect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0679387622604743
unesp.author.lattes6758680388835078
unesp.author.lattes8727897080522289[4]
unesp.author.orcid0000-0002-7003-9643[2]
unesp.author.orcid0000-0002-7719-9682[4]
unesp.author.orcid0000-0003-4761-4336[5]
unesp.author.orcid0000-0002-4753-3264[1]
unesp.author.orcid0000-0002-9227-832X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB
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