Upper gastrointestinal histopathological findings in children and adolescents with nonulcer dyspepsia with helicobacter pylori infection

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dc.contributor.authorCarvalho, Mary de Assis [UNESP]
dc.contributor.authorMachado, Nilton Carlos [UNESP]
dc.contributor.authorOrtolan, Érika Veruska Paiva [UNESP]
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:32:39Z
dc.date.available2014-05-20T13:32:39Z
dc.date.issued2012-11-01
dc.description.abstractObjectives: The aim of the study was to investigate the histopathological lesions in the upper gastrointestinal mucosa associated with Helicobacter pylori infection in children with nonulcer dyspepsia.Methods: A cross-sectional case-control study was performed on 185 Brazilian children and adolescents (4-17 years, mean 9.5 +/- 2.7 years), 63.2% girls, submitted to upper gastrointestinal endoscopy. The histopathological lesions of the esophageal and gastric mucosa were analyzed in biopsy samples.Results: H pylori infection was identified in 96 children (51.8%). Moderate to severe chronic active gastritis was present in antrum (70.5%) and corpus (45.2%), with higher grading in antrum than in corpus (P<0.05). The topographic distribution of inflammation was pangastritis (61.9%), followed by antral (32.1%) and corpus (5.9%). H pylori density was higher in antrum than in corpus. Intestinal metaplasia was not found in the H pylori-infected group, nor was significant gastric atrophy. The scores for esophagitis were significantly higher (P<0.05) in the noninfected group (1.4 +/- 0.8) than in the H pylori-infected group (1.07 +/- 0.9), with significant negative correlation (r = 0.29; P<0.05) with the scores of gastric inflammation.Conclusions: The prevalence of H pylori infection was high among children with dyspepsia and associated with moderate/severe degrees of gastric inflammation. The high scores of esophagitis in the noninfected group point to 2 distinct groups of pathological conditions sharing similar clinical patterns.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Pediatria, Botucatu, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Patologia, Botucatu, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Cirurgia e Ortopedia, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Pediatria, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Patologia, Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu (FMB), Departamento de Cirurgia e Ortopedia, Botucatu, SP, Brasil
dc.format.extent523-529
dc.identifierhttp://dx.doi.org/10.1097/MPG.0b013e3182618136
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 55, n. 5, p. 523-529, 2012.
dc.identifier.doi10.1097/MPG.0b013e3182618136
dc.identifier.issn0277-2116
dc.identifier.lattes4729603720628835
dc.identifier.lattes1576374151262910
dc.identifier.urihttp://hdl.handle.net/11449/11142
dc.identifier.wosWOS:000310571700015
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.relation.ispartofjcr2.752
dc.relation.ispartofsjr1,376
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectChildhooden
dc.subjectDyspepsiaen
dc.subjectEsophagitisen
dc.subjectGastritisen
dc.subjectHelicobacter pylori infectionen
dc.titleUpper gastrointestinal histopathological findings in children and adolescents with nonulcer dyspepsia with helicobacter pylori infectionen
dc.typeArtigo
dcterms.licensehttp://edmgr.ovid.com/spine/accounts/copyrightTransfer.pdf
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.advisor.lattes4729603720628835
unesp.author.lattes1576374151262910
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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