Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiol

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dc.contributor.authorLeonel, Ellen Cristina Rivas [UNESP]
dc.contributor.authorRuiz, Thalles Fernando Rocha [UNESP]
dc.contributor.authorBedolo, Carolina Marques [UNESP]
dc.contributor.authorCampos, Silvana Gisele Pegorin [UNESP]
dc.contributor.authorTaboga, Sebastião Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2022-05-01T07:58:48Z
dc.date.available2022-05-01T07:58:48Z
dc.date.issued2021-01-01
dc.description.abstractThe mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17-β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho-STAT3 (P-STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor-α, COX-2, P-STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG.en
dc.description.affiliationDepartment of Biology Humanities and Exact Sciences Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Histology Embriology and Cell Biology Institute of Biological Sciences (ICB III) Federal University of Goiás (UFG)
dc.description.affiliationUnespDepartment of Biology Humanities and Exact Sciences Institute of Biosciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1002/cbin.11665
dc.identifier.citationCell Biology International.
dc.identifier.doi10.1002/cbin.11665
dc.identifier.issn1095-8355
dc.identifier.issn1065-6995
dc.identifier.scopus2-s2.0-85111684137
dc.identifier.urihttp://hdl.handle.net/11449/233342
dc.language.isoeng
dc.relation.ispartofCell Biology International
dc.sourceScopus
dc.subjectendocrine disruptor
dc.subjectfemale prostate
dc.subjectinflammation
dc.subjectmammary gland
dc.subjectmorphology
dc.titleInflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-β estradiolen
dc.typeArtigo
unesp.author.orcid0000-0002-4597-3346[1]
unesp.author.orcid0000-0003-0544-8325[2]
unesp.author.orcid0000-0002-0970-4288[5]

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