Recent advances in the use of Galleria mellonella model to study immune responses against human pathogens

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dc.contributor.authorPereira, Thais Cristine [UNESP]
dc.contributor.authorBarros, Patrícia Pimentel de [UNESP]
dc.contributor.authorde Oliveira Fugisaki, Luciana Ruano [UNESP]
dc.contributor.authorRossoni, Rodnei Dennis [UNESP]
dc.contributor.authorRibeiro, Felipe de Camargo [UNESP]
dc.contributor.authorMenezes, Raquel Teles de [UNESP]
dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:08:53Z
dc.date.available2019-10-06T16:08:53Z
dc.date.issued2018-01-01
dc.description.abstractThe use of invertebrates for in vivo studies in microbiology is well established in the scientific community. Larvae of Galleria mellonella are a widely used model for studying pathogenesis, the efficacy of new antimicrobial compounds, and immune responses. The immune system of G. mellonella larvae is structurally and functionally similar to the innate immune response of mammals, which makes this model suitable for such studies. In this review, cellular responses (hemocytes activity: phagocytosis, nodulation, and encapsulation) and humoral responses (reactions or soluble molecules released in the hemolymph as antimicrobial peptides, melanization, clotting, free radical production, and primary immunization) are discussed, highlighting the use of G. mellonella as a model of immune response to different human pathogenic microorganisms.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), São José dos Campos
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), São José dos Campos
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2016/25544-1 (FCR)
dc.description.sponsorshipIdFAPESP: 2017/02652-6 (PPB)
dc.description.sponsorshipIdFAPESP: 2017/19219-3 (RDR)
dc.identifierhttp://dx.doi.org/10.3390/jof4040128
dc.identifier.citationJournal of Fungi, v. 4, n. 4, 2018.
dc.identifier.doi10.3390/jof4040128
dc.identifier.issn2309-608X
dc.identifier.scopus2-s2.0-85058053342
dc.identifier.urihttp://hdl.handle.net/11449/188464
dc.language.isoeng
dc.relation.ispartofJournal of Fungi
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntimicrobial peptides
dc.subjectClotting
dc.subjectExperimental model
dc.subjectFree radical production
dc.subjectGalleria mellonella
dc.subjectHemocytes
dc.subjectImmune response
dc.subjectIn vivo study
dc.subjectMelanization
dc.subjectPrimary immunization
dc.titleRecent advances in the use of Galleria mellonella model to study immune responses against human pathogensen
dc.typeResenha

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