Differential behavioral and neuroendocrine effects of repeated nicotine in adolescent and adult rats

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dc.contributor.authorCruz, F. C.
dc.contributor.authorDeLucia, R.
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:27Z
dc.date.available2014-05-20T13:24:27Z
dc.date.issued2005-03-01
dc.description.abstractDespite the high prevalence of tobacco abuse among adolescents, the neurobiology of nicotine addiction has been studied mainly in adult animals. Repeated administration of this drug to adult rats induces behavioral sensitization. Nicotine activates the HPA axis in adult rats as measured by drug-induced increases in ACTH and corticosterone. Both behavioral sensitization and corticosterone are implicated in drug addiction. We examined the expression of behavioral sensitization induced by nicotine as well as the changes in corticosterone levels after repeated injections of nicotine in adolescent and adult animals. Adolescent and adult rats received subcutaneous (s.c.) injections of saline or 0.4 mg/kg of nicotine once daily for 7 days. Three days after the last injection animals were challenged with saline or nicotine (0.4 mg/kg; s.c.). Nicotine-induced locomotion was recorded in an activity cage. Trunk blood samples were collected in a subset of adolescent and adult rats and plasma corticosterone levels were determined by radioimmunoassay. Adult, but not adolescent, rats expressed behavioral sensitization. Pretreatment with nicotine abolished corticosterone-activating effect of this drug only in adult animals, indicating the development of tolerance at this age. Our results provide evidence that adolescent rats exposed to repeated nicotine display behavioral and neuroendocrine adaptations distinct from that observed in adult animals. (c) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Lab Psychopharmacol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.format.extent411-417
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2004.12.007
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 80, n. 3, p. 411-417, 2005.
dc.identifier.doi10.1016/j.pbb.2004.12.007
dc.identifier.issn0091-3057
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/7592
dc.identifier.wosWOS:000227732200007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectnicotinept
dc.subjectbehavioral sensitizationpt
dc.subjectcorticosteronept
dc.subjectlocomotor activitypt
dc.subjectadultpt
dc.subjectadolescentpt
dc.subjectratpt
dc.titleDifferential behavioral and neuroendocrine effects of repeated nicotine in adolescent and adult ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2514762545280942[3]
unesp.author.orcid0000-0002-1378-6327[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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