Genetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazon

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dc.contributor.authorCampos, Melina [UNESP]
dc.contributor.authorAlonso, Diego Peres [UNESP]
dc.contributor.authorConn, Jan E.
dc.contributor.authorVinetz, Joseph M.
dc.contributor.authorEmerson, Kevin J.
dc.contributor.authorRibolla, Paulo Eduardo Martins [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity at Albany (State University of New York)
dc.contributor.institutionNew York State Department of Health
dc.contributor.institutionSan Diego
dc.contributor.institutionUniversidad Peruana Cayetano Heredia
dc.contributor.institutionSt. Mary's College of Maryland
dc.date.accessioned2019-10-06T17:09:58Z
dc.date.available2019-10-06T17:09:58Z
dc.date.issued2019-05-17
dc.description.abstractBackground: In the Amazon Basin, Nyssorhynchus (Anopheles) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline vectors such as host preference, biting time and resting location post blood meal have a key impact on malaria transmission dynamics and vector control interventions. Nyssorhynchus darlingi presents a range of feeding and resting behaviors throughout its broad distribution. Methods: To investigate the genetic diversity related to biting behavior, we collected host-seeking Ny. darlingi in two settlement types in Acre, Brazil: Granada (~ 20-year-old, more established, better access by road, few malaria cases) and Remansinho (~ 8-year-old, active logging, poor road access, high numbers malaria cases). Mosquitoes were classified by the location of collection (indoors or outdoors) and time (dusk or dawn). Results: Genome-wide SNPs, used to assess the degree of genetic divergence and population structure, identified non-random distributions of individuals in the PCA for both location and time analyses. Although genetic diversity related to behavior was confirmed by non-model-based analyses and F ST values, model-based STRUCTURE detected considerable admixture of these populations. Conclusions: To our knowledge, this is the first study to detect genetic markers associated with biting behavior in Ny. darlingi. Additional ecological and genomic studies may help to understand the genetic basis of mosquito behavior and address appropriate surveillance and vector control.en
dc.description.affiliationBiotechnology Institute (IBTEC) Biosciences Institute at Botucatu (IBB) Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Biomedical Sciences School of Public Health University at Albany (State University of New York)
dc.description.affiliationWadsworth Center New York State Department of Health
dc.description.affiliationDivision of Infectious Diseases Department of Medicine University of California San Diego
dc.description.affiliationLaboratorio de Investigación y Desarrollo Departamento de Ciencias Celulares y Moleculares Instituto de Medicina Tropical Alexander von Humboldt Universidad Peruana Cayetano Heredia
dc.description.affiliationBiology Department St. Mary's College of Maryland
dc.description.affiliationUnespBiotechnology Institute (IBTEC) Biosciences Institute at Botucatu (IBB) Sao Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1186/s13071-019-3498-4
dc.identifier.citationParasites and Vectors, v. 12, n. 1, 2019.
dc.identifier.doi10.1186/s13071-019-3498-4
dc.identifier.issn1756-3305
dc.identifier.lattes3577149748456880
dc.identifier.orcid0000-0001-8735-6090
dc.identifier.scopus2-s2.0-85065895778
dc.identifier.urihttp://hdl.handle.net/11449/190341
dc.language.isoeng
dc.relation.ispartofParasites and Vectors
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiting behavior
dc.subjectGenetic heterogeneity
dc.subjectGenetic population
dc.subjectIndividual mosquito scale
dc.subjectMalaria vector
dc.subjectNyssorhynchus (Anopheles) darlingi
dc.subjectSNPs
dc.titleGenetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazonen
dc.typeArtigo
unesp.author.lattes3577149748456880[6]
unesp.author.orcid0000-0001-8735-6090[6]

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