Role of brain nitric oxide in the thermoregulation of broiler chicks

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dc.contributor.authorColeone, A. C. [UNESP]
dc.contributor.authorTorres, K. A. A. [UNESP]
dc.contributor.authorCarnio, E. C.
dc.contributor.authorGargaglioni, L. H. [UNESP]
dc.contributor.authorMacari, Marcos [UNESP]
dc.contributor.authorFurlan, Renato Luis [UNESP]
dc.contributor.authorBicego, K. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:15:36Z
dc.date.available2014-05-20T13:15:36Z
dc.date.issued2009-10-01
dc.description.abstractNitric oxide (NO) plays a key role in body temperature (Tb) regulation of mammals, acting on the brain to stimulate heat loss. Regarding birds, the putative participation of NO in the maintenance of Tb in thermoneutrality or during heat stress and the site of its action (periphery or brain) is unknown. Thus, we tested if NO participates in the maintenance of chicks' Tb in those conditions. We investigated the effect of intramuscular (im; 25, 50, 100 mg/kg) or intracerebroventricular (icv; 22.5, 45, 90, 180 mu g/animal) injections of the non selective NO synthase inhibitor L-NAME on Tb of 5-day-old chicks at thermoneutral zone (TNZ; 31-32 degrees C) and under heat stress (37 degrees C for 5-6 h). We also verified plasma and diencephalic nitrite/nitrate levels in non-injected chicks under both conditions. At TNZ, 100 mg/kg (im) or 45,90,180 mu g (icv) of L-NAME decreased Tb. A significant correlation between Tb and diencephalic, but not plasma, nitrite/nitrate levels was observed. Heat stress-induced hyperthermia was inhibited by all tested doses of L-NAME (im and icv). Tb was correlated neither with plasma nor with diencephalic nitrite/nitrate levels during heat stress. These results indicate the involvement of brain NO in the maintenance of Tb of chicks, an opposite action of that observed in mammals, and may modulate hyperthermia. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, Coll Agr & Vet Sci, Dept Anim Morphol & Physiol, BR-14884900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Nursing Sch Ribeirao Preto, BR-14014090 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Coll Agr & Vet Sci, Dept Anim Morphol & Physiol, BR-14884900 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 06/59669-3
dc.format.extent204-210
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2009.06.005
dc.identifier.citationComparative Biochemistry and Physiology A-molecular & Integrative Physiology. New York: Elsevier B.V., v. 154, n. 2, p. 204-210, 2009.
dc.identifier.doi10.1016/j.cbpa.2009.06.005
dc.identifier.issn1095-6433
dc.identifier.lattes5713558572926669
dc.identifier.lattes0806409484159642
dc.identifier.orcid0000-0001-9549-0329
dc.identifier.urihttp://hdl.handle.net/11449/2703
dc.identifier.wosWOS:000269025200005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry and Physiology A-molecular & Integrative Physiology
dc.relation.ispartofjcr2.258
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCentral nervous systemen
dc.subjectHeat stressen
dc.subjectL-NAMEen
dc.subjectNitriteen
dc.subjectNitrateen
dc.titleRole of brain nitric oxide in the thermoregulation of broiler chicksen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5713558572926669
unesp.author.lattes0806409484159642[6]
unesp.author.orcid0000-0002-6850-7145[5]
unesp.author.orcid0000-0001-9549-0329[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV