Behavioural alterations provoked by prolonged calcitonin administration in rats

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dc.contributor.authorArone, Ana Elisa F. [UNESP]
dc.contributor.authorDe Aguiar, Daniele Cristina [UNESP]
dc.contributor.authorGodinho, Antônio Francisco [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:41Z
dc.date.available2014-05-27T11:20:41Z
dc.date.issued2003-07-01
dc.description.abstractPresent work investigated the effect of prolonged administration of salmon calcitonin, a hormone secreted by parafollicular cells from thyroid, on behavioural parameters of rats. Animals received calcitonin sc, 100 mUI/100 g of body weight, three times a week, during 50 days. Behaviour was assessed utilizing an Open Field, Elevated Plus-Maze and Hole Board apparatus. Calcitonin treatment in rats seems to modify open field and elevated plus maze behaviour, suggesting emotionality and anxiety state alterations of the animals. These conditions can be provoked due to the direct calcitonin action on its receptors, even though we do not exclude an action mediated by tissue calcium level alterations.en
dc.description.affiliationCtr. Toxicol. Assistance (CEATOX) Biosciences Institute Univ. Estadual Paulista (UNESP), Botucatu, SP
dc.description.affiliationUniv. Estadual Paulista (UNESP) Instituto de Biociências Ctro. Assistencia Toxicol. (CEATOX), Rubiao Junior s/n, 18618-000 - Botucatu, S.P.
dc.description.affiliationUnespCtr. Toxicol. Assistance (CEATOX) Biosciences Institute Univ. Estadual Paulista (UNESP), Botucatu, SP
dc.description.affiliationUnespUniv. Estadual Paulista (UNESP) Instituto de Biociências Ctro. Assistencia Toxicol. (CEATOX), Rubiao Junior s/n, 18618-000 - Botucatu, S.P.
dc.format.extent5-9
dc.identifier.citationRevista Brasileira de Toxicologia, v. 16, n. 1, p. 5-9, 2003.
dc.identifier.issn1415-2983
dc.identifier.scopus2-s2.0-0141573155
dc.identifier.urihttp://hdl.handle.net/11449/67354
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Toxicologia
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBehavioren
dc.subjectCalcitoninen
dc.subjectElevated-Plus-Mazeen
dc.subjectHole Boarden
dc.subjectOpen Fielden
dc.subjectRaten
dc.subjectcalcitoninen
dc.subjectanimal behavioren
dc.subjectanimal experimenten
dc.subjectbehavioren
dc.subjectcontrolled studyen
dc.subjectemotionalityen
dc.subjectmaleen
dc.subjectmaze testen
dc.subjectnonhumanen
dc.subjectopen field behavioren
dc.subjectraten
dc.subjectthyroid glanden
dc.subjectthyroid parafollicular cellen
dc.subjecttissue levelen
dc.subjectAnimaliaen
dc.titleBehavioural alterations provoked by prolonged calcitonin administration in ratsen
dc.typeArtigo
unesp.author.lattes9719891659222257[3]
unesp.author.orcid0000-0002-2832-8919[3]

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Botucatu - CEATOX - Centro de Assistência Toxicológica