Atherosclerotic carotid disease and cardiovascular risk in HIV-Infected patients

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dc.contributor.authorHueb, J. C. [UNESP]
dc.contributor.authorSalmazo, Péricles [UNESP]
dc.contributor.authorBarbosa, Alexandre Naime [UNESP]
dc.contributor.authorTerribilli, R. [UNESP]
dc.contributor.authorMatsubara, B. B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-07-07T12:38:17Z
dc.date.available2016-07-07T12:38:17Z
dc.date.issued2013
dc.description.abstractIntroduction Although survival has been improved in HIV-infected patients, the risk for atherosclerotic diseases has increased. Objective To evaluate the effect of HIV infection on atherosclerosis in asymptomatic patients. Subjects and methods Study design: observational, prospective case-control study, including 124 consecutive male and female HIV-infected patients, older than 18 year (HIV-group). Results were compared with 130 healthy volunteers of same gender and age (Control-group). Study protocol: Clinical evaluation followed by ultrasound exam of carotids for carotid intimal-medial thickness (CIMT) measurement. The presence of atherosclerosis plaques was recorded. Statistical analysis: Chi-square test and linear regression analysis. Significance level: p < 0.05. Result Age (HIV-group:43.87 ± 11.31 vs Control-group: 42.9 ± 11.54, p = 0.324) was similar in both groups. There was 52.00% male in HIV-group and 54.00% in Control group. Atherosclerotic plaque was identified in 30.64% of the patients HIV and in 3.84% of the control (p < 0.001). Surprisingly, 22% of HIV-infected patients, classified at low risk score Freminghan, presented plaques in the carotid arteries. For controls, there was an increase of 0.068 mm in the CIMT for each one-year increase in age (OR: 1.068; CI95%: 1.03–1.107; p < 0.001). The presence of HIV increased this increment for tenfold (OR: 10.7; CI95%: 3.58–31.76; p < 0.001). There was an interaction between age and HIV-infection to increase CIMT (p < 0.001). Conclusions Our results indicated that: 1- patients with HIV are at higher risk for atherosclerosis in the carotid artery than control individuals. 2- The effect of age on risk for atherosclerosis occurs in both groups, however it is more remarkable in HIV-infected patients.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu - Departamento de Doenças Tropicais, Botucatu, Distrito de Rubião Jr, s/n - Depto. de Doenças Tropicais e Diagnóstico por Imagem - Unesp, Distrito de Rubião Jr., CEP 18618970, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu - Departamento de Doenças Tropicais, Botucatu, Distrito de Rubião Jr, s/n - Depto. de Doenças Tropicais e Diagnóstico por Imagem - Unesp, Distrito de Rubião Jr., CEP 18618970, SP, Brasil
dc.format.extentA368-A369
dc.identifierhttp://dx.doi.org/10.1136/sextrans-2013-051184.1152
dc.identifier.citationSexually Transmitted Infections, v. 89, n. Suppl 1, p. A368-A369, 2013.
dc.identifier.doi10.1136/sextrans-2013-051184.1152
dc.identifier.issn1368-4973
dc.identifier.lattes6990977122340795
dc.identifier.lattes6990977122340795
dc.identifier.lattes6990977122340795
dc.identifier.urihttp://hdl.handle.net/11449/141430
dc.language.isoeng
dc.relation.ispartofSexually Transmitted Infections
dc.relation.ispartofjcr3.346
dc.relation.ispartofsjr1,626
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleAtherosclerotic carotid disease and cardiovascular risk in HIV-Infected patientsen
dc.typeArtigo
unesp.author.lattes6990977122340795
unesp.author.lattes6242355280094109[3]
unesp.author.orcid0000-0002-2187-4722[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Doenças Tropicais e Diagnósticos por Imagem - FMB