Lobe Variation Effects of Experimental Diabetes and Insulin Replacement on Rat Prostate

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dc.contributor.authorPorto, Elaine Manoela
dc.contributor.authorDe Alcantara Dos Santos, Sergio Alexandre [UNESP]
dc.contributor.authorRibeiro, Larissa Mayumi [UNESP]
dc.contributor.authorLacorte, Livia Maria [UNESP]
dc.contributor.authorRinaldi, Jaqueline Carvalho [UNESP]
dc.contributor.authorJustulin, Luis Antonio
dc.contributor.authorFelisbino, Sergio Luis [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual do Oeste do Paraná (UNIOESTE)
dc.contributor.institutionUniversidade Federal do Triângulo Mineiro (UFTM)
dc.date.accessioned2014-05-20T13:51:59Z
dc.date.available2014-05-20T13:51:59Z
dc.date.issued2011-11-01
dc.description.abstractWe investigated the impact of diabetes with simultaneous and late insulin replacement on rat prostate growth during puberty, paying special attention to different prostatic lobes. Diabetes was induced by administration of streptozotocin (STZ) in 40-day-old male Wistar rats. A subset of diabetic rats underwent simultaneous insulin replacement (3 days after STZ administration), and another subset underwent a late insulin replacement (20 days after STZ administration). The ventral, dorsolateral, and anterior prostatic lobes were weighed and processed for histological, immunohistochemical, and morphometric analyses. Both diabetic and insulin-treated animals maintained low plasma testosterone (T) concentrations, whereas dihydrotestostenore (DHT) levels were normal. Diabetic animals had a decreased gain in absolute prostatic weight when compared to age-matched controls and insulin replacement animals. However, prostatic lobe weight in the diabetic animals was similar to 100% higher, even at the beginning of the experiment. Among the lobes, the anterior lobe showed the highest weight gain in diabetic and insulin replacement conditions. Epithelial cell proliferation in all lobes was significantly reduced in diabetic animals and significantly increased in insulin replacement animals, although apoptosis was unaltered. In conclusion, diabetes diminishes, but does not abolish, prostate growth during puberty. Even late insulin administration reduces the adverse effects of this disease on the prostate. In a scenario with both low insulin and T levels, DHT and other factors may play an important role in pubertal prostate growth. The adverse effects of diabetes on the rat prostate show a variation in lobe response, suggesting that diabetes may affect human prostate zones differently. Microsc. Res. Tech. 74:1040-1048, 2011. (C) 2011 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Inst Biol, São Paulo, Brazil
dc.description.affiliationState Univ W Parana UNIOESTE, Ctr Biol & Hlth Sci CCBS, Cascavel, Parana, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Uberaba, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 06/60115-2
dc.description.sponsorshipIdFAPESP: 06/60116-9
dc.description.sponsorshipIdCNPq: 476137/03-9
dc.format.extent1040-1048
dc.identifierhttp://dx.doi.org/10.1002/jemt.20991
dc.identifier.citationMicroscopy Research and Technique. Malden: Wiley-blackwell, v. 74, n. 11, p. 1040-1048, 2011.
dc.identifier.doi10.1002/jemt.20991
dc.identifier.issn1059-910X
dc.identifier.lattes7263490918934874
dc.identifier.urihttp://hdl.handle.net/11449/18573
dc.identifier.wosWOS:000297410900008
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.ispartofjcr1.087
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectprostateen
dc.subjectdiabetesen
dc.subjectcell proliferationen
dc.subjectapoptosisen
dc.subjectinsulinen
dc.titleLobe Variation Effects of Experimental Diabetes and Insulin Replacement on Rat Prostateen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes7263490918934874
unesp.author.orcid0000-0002-2960-4559[4]
unesp.author.orcid0000-0001-6142-3515[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Morfologia - IBB