Experimental systemic virulence of oral Candida dubliniensis isolates in comparison with Candida albicans, Candida tropicalis and Candida krusei

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dc.contributor.authorKoga-Ito, Cristiane Yumi [UNESP]
dc.contributor.authorKomiyama, Edson Yukio [UNESP]
dc.contributor.authorde Paiva Martins, Clelia Aparecida [UNESP]
dc.contributor.authorVasconcellos, Thassia Castro [UNESP]
dc.contributor.authorCardoso Jorge, Antonio Olavo [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.authordo Prado, Renata Falchete [UNESP]
dc.contributor.authorBalducci, Ivan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:27Z
dc.date.available2014-05-20T14:04:27Z
dc.date.issued2011-09-01
dc.description.abstractThere are no previous studies on the comparative virulence of Candida dubliniensis with other non-albicans species. The aim of this study was to compare the virulence and infection kinetics of C. dubliniensis and other species. Candida albicans, C. dubliniensis, Candida tropicalis and Candida krusei (reference strains) were inoculated intravenously in mice. For infection kinetics evaluation, a group of five animals were sacrificed after 6 h, 3, 7, 14 and 21 days. Microbiological evaluations (liver, spleen, kidneys, lungs and brain) and histopathological examination of the kidney were performed. The results of virulence evaluation were analysed using Kaplan-Meier survival analysis (5%). Candida dubliniensis-inoculated mice survived for longer periods compared with those with C. albicans (P = 0.005). No differences were detected in relation to C. tropicalis (P = 0.326) and C. krusei (P = 0.317). Most of the organs were persistently colonised by C. albicans and C. dubliniensis even by day 21. Tendency of C. krusei clearance was observed in all organs. Fungal masses and renal lesions were observed after inoculation of C. albicans, C. dubliniensis and C. tropicalis. Within the limits of the study, data on survival rate and dissemination capacity suggest that C. dubliniensis is less virulent than C. albicans.en
dc.description.affiliationUniv Estadual Paulista UNESP, Sao Jose Campos Dent Sch, Dept Oral Biosci & Diag, Microbiol Lab, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Sao Jose Campos Dent Sch, Dept Oral Biosci & Diag, Lab Pathol, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Sao Jose Campos Dent Sch, Dept Oral Biosci & Diag, Microbiol Lab, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Sao Jose Campos Dent Sch, Dept Oral Biosci & Diag, Lab Pathol, Sao Jose Dos Campos, SP, Brazil
dc.format.extentE278-E285
dc.identifierhttp://dx.doi.org/10.1111/j.1439-0507.2010.01899.x
dc.identifier.citationMycoses. Malden: Wiley-blackwell, v. 54, n. 5, p. E278-E285, 2011.
dc.identifier.doi10.1111/j.1439-0507.2010.01899.x
dc.identifier.issn0933-7407
dc.identifier.lattes0053567153623569
dc.identifier.lattes6967369119792151
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.urihttp://hdl.handle.net/11449/22609
dc.identifier.wosWOS:000294878900092
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMycoses
dc.relation.ispartofjcr2.793
dc.relation.ispartofsjr1,069
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCandida dubliniensisen
dc.subjectvirulenceen
dc.subjectpathogenicityen
dc.subjectCandida spp.en
dc.titleExperimental systemic virulence of oral Candida dubliniensis isolates in comparison with Candida albicans, Candida tropicalis and Candida kruseien
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes0053567153623569[5]
unesp.author.lattes6967369119792151
unesp.author.lattes6543563161403421[1]
unesp.author.orcid0000-0002-1747-6158[5]
unesp.author.orcid0000-0002-2416-2173[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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