INCREASED CALCIUM AFFINITY OF A FUCOSYLATED CHONDROITIN SULFATE FROM SEA-CUCUMBER

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dc.contributor.authorRuggiero, J.
dc.contributor.authorVieira, R. P.
dc.contributor.authorMourao, PAS
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:31Z
dc.date.available2014-05-20T15:26:31Z
dc.date.issued1994-04-01
dc.description.abstractCalcium binding and charge distribution on a fucosylated chondroitin sulfate and a standard chondroitin 6-sulfate have been studied using a metallochromic indicator and conductimetric titrations. The fucosylated chondroitin sulfate has a similar to 5-fold greater affinity for calcium ions than the standard chondroitin 6-sulfate. Possibly, this increased affinity for calcium ions is due to the branches on the fucosylated chondroitin sulfate, since the calcium affinity of an unbranched, sulfated fucan is similar to that of the standard chondroitin 6-sulfate. More charged groups per disaccharide unit (and a shorter distance between these groups) also distinguish the fucosylated chondroitin sulfate from standard chondroitin 6-sulfate. Comparison between native and chemically modified (desulfated or carboxyl-reduced) polysaccharides suggests that the sulfate esters are responsible for the increased charge density of the fucosylated chondroitin sulfate and that the presence of the fucose branches does not alter the length of the repetitive units which compose the central core of chondroitin from sea cucumber. These results are consistent with the chemical studies of these two polysaccharides.en
dc.description.affiliationFED UNIV RIO DE JANEIRO,INST CIENCIAS BIOMED,DEPT BIOQUIM,BR-21941590 RIO JANEIRO,BRAZIL
dc.description.affiliationUNIV ESTADUAL JULIO MESQUITA FILHO,INST BIOCIENCIAS LETRAS & CIENCIAS EXACTAS,DEPT FIS,BR-15054000 S JOSE RIO PR,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL JULIO MESQUITA FILHO,INST BIOCIENCIAS LETRAS & CIENCIAS EXACTAS,DEPT FIS,BR-15054000 S JOSE RIO PR,SP,BRAZIL
dc.format.extent275-287
dc.identifierhttp://dx.doi.org/10.1016/0008-6215(94)84213-2
dc.identifier.citationCarbohydrate Research. Amsterdam: Elsevier B.V., v. 256, n. 2, p. 275-287, 1994.
dc.identifier.doi10.1016/0008-6215(94)84213-2
dc.identifier.issn0008-6215
dc.identifier.urihttp://hdl.handle.net/11449/36683
dc.identifier.wosWOS:A1994NE72900005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Research
dc.relation.ispartofjcr2.074
dc.relation.ispartofsjr0,617
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleINCREASED CALCIUM AFFINITY OF A FUCOSYLATED CHONDROITIN SULFATE FROM SEA-CUCUMBERen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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