Propolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysis

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dc.contributor.authorSales-Peres, Silvia Helena de Carvalho
dc.contributor.authorde Azevedo-Silva, Lucas José
dc.contributor.authorCastilho, Ana Virginia Santana Sampaio
dc.contributor.authorCastro, Marcelo Salmazo
dc.contributor.authorSales-Peres, Silvia Helena de Carvalho [UNESP]
dc.contributor.authorMoreira Machado, Maria Aparecida de Andrade
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:49:44Z
dc.date.available2023-07-29T13:49:44Z
dc.date.issued2023-01-01
dc.description.abstractThis meta-analysis aimed to investigate the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. PubMed, EMBASE, SciELO, Web of Science, and SCOPUS databases were systematically searched. Studies have been conducted analyzing propolis’s effects on COVID-19 and periodontitis. The study was conducted according to the PRISMA statement and registered in PROSPERO. Risk of Bias (RoB) assessment and meta-analysis of clinical studies were performed (Review Manager 5, Cochrane). The certainty of the evidence was assessed using GradePro (GDT). Studies have shown propolis flavonoids inhibit viral replication in several DNA and RNA viruses, including coronaviruses. Propolis components have an aminopeptidase inhibitor activity that can inhibit the main proteases of SARS viruses and seem to inhibit protein spikes, which are sites of most mutations in SARS-CoV strains. The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001). The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses. Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity. Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.en
dc.description.affiliationUniversidade de São Paulo – USP Bauru School of Dentistry Department of Pediatric Dentistry Orthodontics and Public Health, SP
dc.description.affiliationUniversidade de São Paulo – USP Bauru School of Dentistry Department of Prosthodontics and Periodontics, SP
dc.description.affiliationUniversidade Estadual de São Paulo – UNESP Botucatu Medical School Department of Ophthalmology Otorhinolaryngology and Head and Neck Surgery, SP
dc.description.affiliationUnespUniversidade Estadual de São Paulo – UNESP Botucatu Medical School Department of Ophthalmology Otorhinolaryngology and Head and Neck Surgery, SP
dc.description.sponsorshipUniversidade de São Paulo
dc.description.sponsorshipIdUniversidade de São Paulo: 18/25934-0
dc.identifierhttp://dx.doi.org/10.1590/1807-3107BOR-2023.VOL37.0031
dc.identifier.citationBrazilian Oral Research, v. 37.
dc.identifier.doi10.1590/1807-3107BOR-2023.VOL37.0031
dc.identifier.issn1807-3107
dc.identifier.issn1806-8324
dc.identifier.scopus2-s2.0-85151805275
dc.identifier.urihttp://hdl.handle.net/11449/248645
dc.language.isoeng
dc.relation.ispartofBrazilian Oral Research
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectPeriodontal Diseases
dc.subjectPeriodontitis
dc.subjectPropolis
dc.titlePropolis effects in periodontal disease seem to affect coronavirus disease: a meta-analysisen
dc.typeArtigo
unesp.author.orcid0000-0003-3811-7899[1]
unesp.author.orcid0000-0002-6636-8022[2]
unesp.author.orcid0000-0003-0674-8522[3]
unesp.author.orcid0000-0002-9601-9069[4]
unesp.author.orcid0000-0001-9477-8742[5]
unesp.author.orcid0000-0003-3778-7444[6]

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