Chronic mild prenatal stress exacerbates the allergen-induced airway inflammation in rats

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dc.contributor.authorNogueira, Paulo J. [UNESP]
dc.contributor.authorFerreira, Heloisa H. A.
dc.contributor.authorAntunes, Edson
dc.contributor.authorTeixeira, Nancy A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade São Francisco (USF)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:19:44Z
dc.date.available2014-05-27T11:19:44Z
dc.date.issued1999-06-03
dc.description.abstractThe effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day 14) with ovalbumin. Bronchoalveolar lavage was performed in the offspring at 48 h after intratracheal challenge with ovalbumin. A significant increase in total leukocyte infiltration was observed in the non-stressed offspring group and this was associated with a marked recruitment of eosinophils without a significant effect on the influx of neutrophils and mononuclear cells. In the prenatal stressed offspring, the counts of both total leukocyte and eosinophils, as well as mononuclear cells, was increased by 50% compared to the non-stressed offspring. We provide here the first experimental evidence that chronic mild unpredictable prenatal stress produces a marked increase in the allergen-induced airway inflammation in the rat offspring.en
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUniversidade Sao Francisco, Bragança Paulista, SP
dc.description.affiliationDepartamento de Farmacologia Faculdade de Ciências Medicas UNICAMP, P.O. Boc 6111, 13081-970 Campinas (SP)
dc.description.affiliationUnespDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista, Botucatu, SP
dc.format.extent119-122
dc.identifierhttp://dx.doi.org/10.1080/09629359990621
dc.identifier.citationMediators of Inflammation, v. 8, n. 2, p. 119-122, 1999.
dc.identifier.doi10.1080/09629359990621
dc.identifier.file2-s2.0-0032979193.pdf
dc.identifier.issn0962-9351
dc.identifier.scopus2-s2.0-0032979193
dc.identifier.urihttp://hdl.handle.net/11449/65792
dc.identifier.wosWOS:000080836400008
dc.language.isoeng
dc.relation.ispartofMediators of Inflammation
dc.relation.ispartofjcr3.549
dc.relation.ispartofsjr1,370
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAsthma
dc.subjectDevelopment
dc.subjectEosinophils
dc.subjectLungs
dc.subjectPrenatal stress
dc.subjectovalbumin
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectasthma
dc.subjectcell infiltration
dc.subjecteosinophil
dc.subjectinflammation
dc.subjectlung lavage
dc.subjectmononuclear cell
dc.subjectnonhuman
dc.subjectprediction
dc.subjectprenatal care
dc.subjectpriority journal
dc.subjectprogeny
dc.subjectrat
dc.subjectstress
dc.subjectAllergens
dc.subjectAnimals
dc.subjectBronchial Hyperreactivity
dc.subjectFemale
dc.subjectFood Deprivation
dc.subjectHousing, Animal
dc.subjectInflammation
dc.subjectLeukocyte Count
dc.subjectOvalbumin
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStress, Psychological
dc.subjectWater Deprivation
dc.subjectAnimalia
dc.titleChronic mild prenatal stress exacerbates the allergen-induced airway inflammation in ratsen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/aaa/guidelines/
unesp.author.orcid0000-0003-2201-8247[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Farmacologia - IBB