KCNJ11 gene expression is associated to feed consumption and growth traits in Nelore beef cattle

Página do item simplificado
dc.contributor.authorDiniz, Wellison J.S.
dc.contributor.authorRosa, Kamila O. [UNESP]
dc.contributor.authorCoutinho, Luiz L.
dc.contributor.authorTizioto, Polyana C.
dc.contributor.authorde Oliveira, Priscila S.N.
dc.contributor.authorde Souza, Marcela M.
dc.contributor.authorChaves, Amália S.
dc.contributor.authorLanna, Dante P.D.
dc.contributor.authorMourão, Gerson B.
dc.contributor.authorRegitano, Luciana C.A.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2018-12-11T17:20:46Z
dc.date.available2018-12-11T17:20:46Z
dc.date.issued2018-09-01
dc.description.abstractFeed efficiency is a complex trait influenced by several genes and biological processes. However, there is limited knowledge about the genes and pathways involved in this trait. KCNJ11, related to the insulin secretion pathway, was shown to be a functional candidate gene for beef quality traits in Nelore. Given its role in energy metabolism, we evaluated the effects of KCNJ11 gene expression level on feed efficiency-related, carcass and growth traits in Nelore steers. Skeletal muscle KCNJ11 mRNA levels were positively and significantly associated with dry matter intake (DMI), total digestible nutrients consumption (TDN), average daily gain (ADG), and relative growth rate (RGR) from a general linear mixed model approach. Co-expression analysis, using RNA sequencing data obtained from Longissimus dorsi (LD) muscle of 30 Nelore steers, identified key signalling pathways related to the regulation of energy metabolisms, such as mitogen-activated protein kinases and insulin pathways. Our findings indicate a linear relationship between KCNJ11 gene expression and the phenotypic measures for feed intake, weight gain, and relative growth rate in Nelore steers, but not for residual feed intake or fat deposition traits.en
dc.description.affiliationDepartment of Genetics and Evolution Federal University of São Carlos, São Carlos
dc.description.affiliationDepartment of Animal Science School of Agricultural and Veterinary Studies (FCAV) State University of São Paulo (UNESP), Jaboticabal
dc.description.affiliationDepartment of Animal Science Luiz de Queiroz College of Agriculture University of São Paulo ESALQ-USP, Piracicaba
dc.description.affiliationEmbrapa Pecuária Sudeste, São Carlos
dc.description.affiliationInstitute of Agricultural Sciences Federal University of Minas Gerais
dc.description.affiliationUnespDepartment of Animal Science School of Agricultural and Veterinary Studies (FCAV) State University of São Paulo (UNESP), Jaboticabal
dc.format.extent1-4
dc.identifierhttp://dx.doi.org/10.1016/j.aggene.2018.05.004
dc.identifier.citationAgri Gene, v. 9, p. 1-4.
dc.identifier.doi10.1016/j.aggene.2018.05.004
dc.identifier.issn2352-2151
dc.identifier.scopus2-s2.0-85048304972
dc.identifier.urihttp://hdl.handle.net/11449/176429
dc.language.isoeng
dc.relation.ispartofAgri Gene
dc.relation.ispartofsjr0,130
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAverage daily gain
dc.subjectDry matter intake
dc.subjectInsulin pathway
dc.subjectRelative growth rate
dc.subjectTotal digestible nutrients consumption
dc.titleKCNJ11 gene expression is associated to feed consumption and growth traits in Nelore beef cattleen
dc.typeArtigo

Arquivos

Coleções

Artigos - Zootecnia - FCAV