Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae)

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dc.contributor.authorInácio, Marielle Cascaes [UNESP]
dc.contributor.authorPaz, Tiago Antunes [UNESP]
dc.contributor.authorPereira, Ana Maria Soares
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Ribeirão Preto
dc.date.accessioned2018-12-11T17:32:54Z
dc.date.available2018-12-11T17:32:54Z
dc.date.issued2017-10-01
dc.description.abstractThe root bark of Peritassa campestris (Cambess.) A.C. Sm. (Celastraceae) accumulates quinonemethide triterpenes (QMTs), an important class of bioactive compounds that shows potent antitumor activity. The production of these metabolites is difficult by both chemical synthesis, because of the complex molecular structure, and extraction from plant resources, because of the low yield. Thus, the aim of this work was to evaluate the influence of some important factors on the synthesis of QMTs to increase their production in adventitious roots grown in vitro. The effects of luminosity, mechanical damage to the tissue, source and concentration of carbon, auxins, macronutrient and micronutrient concentrations and the elicitation with its endophytic microorganism, Bacillus megaterium, isolated from roots grown in vitro were evaluated. Additionally, we compared the production of QMTs of roots in vitro with that of P. campestris roots bark in natura. Our results showed that all stimulating agents affected the biosynthesis of QMTs, with the exception of luminosity. The pattern of QMTs produced was different for the in vitro and in natura roots, including the accumulation of the majority QMTs: the in vitro roots accumulated maytenin (1) and 22β-hydroxy-maytenin (2), and the in natura roots showed the accumulation of maytenin (1), 22β-hydroxy-maytenin (2), 20α-hydroxy-maytenin (3), and maytenol (4). Therefore, we concluded that the biosynthesis of QMTs by P. campestris roots is affected by biotic and abiotic factors.en
dc.description.affiliationInstituto de Química Universidade Estadual Paulista - UNESP, Rua Prof. Francisco Degni, 55, Quitandinha
dc.description.affiliationDepartamento de Biotecnologia Vegetal Universidade de Ribeirão Preto
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista - UNESP, Rua Prof. Francisco Degni, 55, Quitandinha
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/19362-2
dc.format.extent15-26
dc.identifierhttp://dx.doi.org/10.1007/s11240-017-1257-9
dc.identifier.citationPlant Cell, Tissue and Organ Culture, v. 131, n. 1, p. 15-26, 2017.
dc.identifier.doi10.1007/s11240-017-1257-9
dc.identifier.file2-s2.0-85021083795.pdf
dc.identifier.issn1573-5044
dc.identifier.issn0167-6857
dc.identifier.lattes1308042794786872
dc.identifier.scopus2-s2.0-85021083795
dc.identifier.urihttp://hdl.handle.net/11449/178960
dc.language.isoeng
dc.relation.ispartofPlant Cell, Tissue and Organ Culture
dc.relation.ispartofsjr0,855
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subject20α-Hydroxy-maytenin
dc.subject22β-Hydroxy-maytenin
dc.subjectElicitation
dc.subjectEndophyte
dc.subjectMaytenin
dc.subjectMaytenol
dc.titleEndophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae)en
dc.typeArtigo
unesp.author.lattes1308042794786872
unesp.author.orcid0000-0002-8434-5238[4]

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Artigos - Química Orgânica - IQ