Temporal Reduction in COVID-19-Associated Fatality Among Kidney Transplant Recipients: The Brazilian COVID-19 Registry Cohort Study

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dc.contributor.authorSandes-Freitas, Tainá Veras de
dc.contributor.authorCristelli, Marina Pontello
dc.contributor.authorRequião-Moura, Lucio Roberto
dc.contributor.authorModelli de Andrade, Luís Gustavo [UNESP]
dc.contributor.authorViana, Laila Almeida
dc.contributor.authorGarcia, Valter Duro
dc.contributor.authorde Oliveira, Claudia Maria Costa
dc.contributor.authorEsmeraldo, Ronaldo de Matos
dc.contributor.authorde Lima, Paula Roberta
dc.contributor.authorCharpiot, Ida Maria Maximina Fernandes
dc.contributor.authorFerreira, Teresa Cristina Alves
dc.contributor.authorFranco, Rodrigo Fontanive
dc.contributor.authorCosta, Kellen Micheline Alves Henrique
dc.contributor.authorSimão, Denise Rodrigues
dc.contributor.authorFerreira, Gustavo Fernandes
dc.contributor.authorSantana, Viviane Brandão Bandeira de Mello
dc.contributor.authorAlmeida, Ricardo Augusto Monteiro de Barros [UNESP]
dc.contributor.authorDeboni, Luciane Monica
dc.contributor.authorSaldanha, Anita Leme da Rocha
dc.contributor.authorNoronha, Irene de Lourdes
dc.contributor.authorOliveira, Lívia Cláudio de
dc.contributor.authorCarvalho, Deise De Boni Monteiro de
dc.contributor.authorOriá, Reinaldo Barreto
dc.contributor.authorMedina-Pestana, Jose Osmar
dc.contributor.authorTedesco-Silva Junior, Helio
dc.contributor.institutionUniversidade Federal do Ceará
dc.contributor.institutionHospital Universitário Walter Cantídio
dc.contributor.institutionHospital Geral de Fortaleza
dc.contributor.institutionHospital do Rim
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHospital Israelita Albert Einstein
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionSanta Casa de Misericórdia de Porto Alegre
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Federal do Maranhão
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul
dc.contributor.institutionHospital Universitário Onofre Lopes (HOUL)
dc.contributor.institutionHospital Santa Isabel
dc.contributor.institutionSanta Casa de Misericórdia de Juiz de Fora
dc.contributor.institutionHospital de Base do Distrito Federal
dc.contributor.institutionHospital Municipal São José (HMSJ)
dc.contributor.institutionHospital Beneficência Portuguesa de São Paulo (BP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionHospital São Francisco na Providência de Deus
dc.date.accessioned2022-04-29T08:46:37Z
dc.date.available2022-04-29T08:46:37Z
dc.date.issued2022-02-01
dc.description.abstractData from the general population suggest that fatality rates declined during the course of the pandemic. This analysis, using data extracted from the Brazilian Kidney Transplant COVID-19 Registry, seeks to determine fatality rates over time since the index case on March 3rd, 2020. Data from hospitalized patients with RT-PCR positive SARS-CoV-2 infection from March to August 2020 (35 sites, 878 patients) were compared using trend tests according to quartiles (Q1: <72 days; Q2: 72–104 days; Q3: 105–140 days; Q4: >140 days after the index case). The 28-day fatality decreased from 29.5% (Q1) to 18.8% (Q4) (pfor-trend = 0.004). In multivariable analysis, patients diagnosed in Q4 showed a 35% reduced risk of death. The trend of reducing fatality was associated with a lower number of comorbidities (20.7–10.6%, pfor-trend = 0.002), younger age (55–53 years, pfor-trend = 0.062), and better baseline renal function (43.6–47.7 ml/min/1.73 m2, pfor-trend = 0.060), and were confirmed by multivariable analysis. The proportion of patients presenting dyspnea (pfor-trend = 0.001) and hypoxemia (pfor-trend < 0.001) at diagnosis, and requiring intensive care was also found reduced (pfor-trend = 0.038). Despite possible confounding variables and time-dependent sampling differences, we conclude that COVID-19-associated fatality decreased over time. Differences in demographics, clinical presentation, and treatment options might be involved.en
dc.description.affiliationPrograma de Pós-Graduação em Ciências Médicas Departamento de Medicina Clínica Faculdade de Medicina Universidade Federal do Ceará
dc.description.affiliationHospital Universitário Walter Cantídio
dc.description.affiliationHospital Geral de Fortaleza
dc.description.affiliationHospital do Rim
dc.description.affiliationDepartamento de Medicina Divisão de Nefrologia Universidade Federal de São Paulo
dc.description.affiliationUnidade de Transplante Renal Hospital Israelita Albert Einstein
dc.description.affiliationDepartamento de Medicina Interna Universidade Estadual Paulista-UNESP
dc.description.affiliationSanta Casa de Misericórdia de Porto Alegre
dc.description.affiliationHospital de Base Faculdade de Medicina de São José do Rio Preto (FAMERP)
dc.description.affiliationUniversidade Federal do Maranhão
dc.description.affiliationHospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul
dc.description.affiliationDivisão de Nefrologia e Transplante Renal Hospital Universitário Onofre Lopes (HOUL)
dc.description.affiliationHospital Santa Isabel
dc.description.affiliationSanta Casa de Misericórdia de Juiz de Fora
dc.description.affiliationHospital de Base do Distrito Federal
dc.description.affiliationHospital Municipal São José (HMSJ)
dc.description.affiliationHospital Beneficência Portuguesa de São Paulo (BP)
dc.description.affiliationDivisão de Nefrologia Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo
dc.description.affiliationUnidade de Transplantes Hospital Universitário de Brasília Universidade de Brasília (UnB)
dc.description.affiliationHospital São Francisco na Providência de Deus
dc.description.affiliationUnespDepartamento de Medicina Interna Universidade Estadual Paulista-UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNovartis Pharma
dc.identifierhttp://dx.doi.org/10.3389/ti.2022.10205
dc.identifier.citationTransplant International, v. 36.
dc.identifier.doi10.3389/ti.2022.10205
dc.identifier.issn1432-2277
dc.identifier.issn0934-0874
dc.identifier.scopus2-s2.0-85124897556
dc.identifier.urihttp://hdl.handle.net/11449/231620
dc.language.isoeng
dc.relation.ispartofTransplant International
dc.sourceScopus
dc.subjectcoronavirus
dc.subjectCovid-19
dc.subjectkidney transplant
dc.subjectrenal transplantation
dc.subjectSars-CoV-2
dc.titleTemporal Reduction in COVID-19-Associated Fatality Among Kidney Transplant Recipients: The Brazilian COVID-19 Registry Cohort Studyen
dc.typeArtigo

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