Interleukin-6 and procalcitonin in children with sepsis and septic shock

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dc.contributor.authorFioretto, José Roberto [UNESP]
dc.contributor.authorMartin, Joelma Gonçalves [UNESP]
dc.contributor.authorKurokawa, Cilmery Suemi [UNESP]
dc.contributor.authorCarpi, Mario Ferreira [UNESP]
dc.contributor.authorBonatto, Rossano César [UNESP]
dc.contributor.authorRicchetti, Sandra M. Q. [UNESP]
dc.contributor.authorde Moraes, Marcos A. [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:38:02Z
dc.date.available2014-05-20T13:38:02Z
dc.date.issued2008-08-01
dc.description.abstractObjectives. To examine the behavior of interleukin-6 (IL-6) and procalcitonin (PCT) and verify whether they can be used to differentiate children with septic conditions. Methods. Septic children aged between 28 days and 14 years, prospectively enrolled from 01/2004 to 12/2005, were divided into sepsis (SG; n = 47) and septic shock (SSG; n = 43) groups. IL-6 and PCT were measured at admission (TO) and 12 h later (T12h). PCT results were classed as: 0.5 ng/mL = sepsis unlikely; >= 0.5 to < 2 = sepsis possible; >= 2 to < 10 = systemic inflammation: >= 10 = septic shock. Results. Ninety children were included. At TO, there was a higher frequency of SSG with higher PCT compared with SG [SSG: 30 (69.7%) > SG: 14 (29.8%): p < 0.051. Similar results were observed at T12h. PRISM was significantly higher for SSG patients with higher PCT than SG patients. At TO, IL-6 levels were higher in SSG [SSG: 213.10 (10.85-396.70) > SG: 63.21 (0.86-409.82); p = 0.001], but not statistically different at T12h. IL-6 levels positively correlated with PRISM score in SSG patients at admission (p = 0.001; r = 0.86). Conclusion. PCT and IL-6 appear to be helpful in early assessment of pediatric sepsis, are of diagnostic value at admission, and are related to disease severity. (c) 2008 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Pediat, Pediat Intens Care Unit, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Expt Res Ctr, Dept Pediat, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Botucatu Inst Biosci, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Botucatu Med Sch, Dept Pediat, Pediat Intens Care Unit, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Expt Res Ctr, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Botucatu Inst Biosci, Dept Biosci, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/03776-0
dc.format.extent160-164
dc.identifierhttp://dx.doi.org/10.1016/j.cyto.2008.05.005
dc.identifier.citationCytokine. London: Academic Press Ltd Elsevier B.V. Ltd, v. 43, n. 2, p. 160-164, 2008.
dc.identifier.doi10.1016/j.cyto.2008.05.005
dc.identifier.issn1043-4666
dc.identifier.lattes8510423269540465
dc.identifier.lattes0246391303241376
dc.identifier.lattes3929692206834380
dc.identifier.orcid0000-0002-0648-876X
dc.identifier.orcid0000-0002-0648-876X
dc.identifier.orcid0000-0003-1380-7527
dc.identifier.urihttp://hdl.handle.net/11449/13194
dc.identifier.wosWOS:000258893600010
dc.language.isoeng
dc.publisherAcademic Press Ltd Elsevier B.V. Ltd
dc.relation.ispartofCytokine
dc.relation.ispartofjcr3.514
dc.relation.ispartofsjr1,433
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectprocalcitoninen
dc.subjectinterleukin-6en
dc.subjectsepsisen
dc.subjectseptic shocken
dc.subjectchildrenen
dc.titleInterleukin-6 and procalcitonin in children with sepsis and septic shocken
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Ltd Elsevier B.V. Ltd
unesp.author.lattes0246391303241376[5]
unesp.author.lattes3929692206834380
unesp.author.lattes8727897080522289[8]
unesp.author.lattes8510423269540465[3]
unesp.author.orcid0000-0002-7719-9682[8]
unesp.author.orcid0000-0003-1380-7527[3]
unesp.author.orcid0000-0002-1482-564X[4]
unesp.author.orcid0000-0002-0648-876X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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