Detection of numerical chromosome anomalies in interphase cells of benign and malignant thyroid lesions using fluorescence in situ hybridization
dc.contributor.author | Barril, N. | |
dc.contributor.author | Carvalho-Sales, A. B. | |
dc.contributor.author | Tajara, E. H. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T14:00:28Z | |
dc.date.available | 2014-05-20T14:00:28Z | |
dc.date.issued | 2000-02-01 | |
dc.description.abstract | Benign and malignant thyroid tumors constitute a wide range of neoplasias showing recurrent chromosome abnormalities. In an attempt to characterize specific numerical chromosome abnormalities in thyroid tissues, We present here the findings from a study of archival samples depicted by 10 malignant tumors, 30 benign lesions, and 10 normal thyroid tissues. Fluorescence in situ hybridization was performed on noncultured samples using biotinylated centromere-specific probes for chromosomes 7, 10, and 17. Trisomy or tetrasomy 7 were present in 19 benign and in 7 malignant tumors. Trisomy 10 or 17 were observed in 18 adenomas or goiters and in 9 carcinomas, and monosomy 17 was seen in 2 carcinomas. Our findings suggest that such abnormalities are an in vivo phenomenon and may be important in the neoplastic proliferation of thyroid gland. (C) Elsevier B.V., 2000. All rights reserved. | en |
dc.description.affiliation | UNESP, IBILCE, Dept Biol, Inst Biociencias Letras & Ciências Exatas Sao Jos, BR-15051000 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, IBILCE, Dept Biol, Inst Biociencias Letras & Ciências Exatas Sao Jos, BR-15051000 Sao Jose do Rio Preto, SP, Brazil | |
dc.format.extent | 50-56 | |
dc.identifier | http://dx.doi.org/10.1016/S0165-4608(99)00143-0 | |
dc.identifier.citation | Cancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 117, n. 1, p. 50-56, 2000. | |
dc.identifier.doi | 10.1016/S0165-4608(99)00143-0 | |
dc.identifier.issn | 0165-4608 | |
dc.identifier.uri | http://hdl.handle.net/11449/21392 | |
dc.identifier.wos | WOS:000085340500010 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Cancer Genetics and Cytogenetics | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Detection of numerical chromosome anomalies in interphase cells of benign and malignant thyroid lesions using fluorescence in situ hybridization | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Biologia - IBILCE | pt |
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