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Detection of numerical chromosome anomalies in interphase cells of benign and malignant thyroid lesions using fluorescence in situ hybridization

dc.contributor.authorBarril, N.
dc.contributor.authorCarvalho-Sales, A. B.
dc.contributor.authorTajara, E. H.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:00:28Z
dc.date.available2014-05-20T14:00:28Z
dc.date.issued2000-02-01
dc.description.abstractBenign and malignant thyroid tumors constitute a wide range of neoplasias showing recurrent chromosome abnormalities. In an attempt to characterize specific numerical chromosome abnormalities in thyroid tissues, We present here the findings from a study of archival samples depicted by 10 malignant tumors, 30 benign lesions, and 10 normal thyroid tissues. Fluorescence in situ hybridization was performed on noncultured samples using biotinylated centromere-specific probes for chromosomes 7, 10, and 17. Trisomy or tetrasomy 7 were present in 19 benign and in 7 malignant tumors. Trisomy 10 or 17 were observed in 18 adenomas or goiters and in 9 carcinomas, and monosomy 17 was seen in 2 carcinomas. Our findings suggest that such abnormalities are an in vivo phenomenon and may be important in the neoplastic proliferation of thyroid gland. (C) Elsevier B.V., 2000. All rights reserved.en
dc.description.affiliationUNESP, IBILCE, Dept Biol, Inst Biociencias Letras & Ciências Exatas Sao Jos, BR-15051000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Biol, Inst Biociencias Letras & Ciências Exatas Sao Jos, BR-15051000 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent50-56
dc.identifierhttp://dx.doi.org/10.1016/S0165-4608(99)00143-0
dc.identifier.citationCancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 117, n. 1, p. 50-56, 2000.
dc.identifier.doi10.1016/S0165-4608(99)00143-0
dc.identifier.issn0165-4608
dc.identifier.urihttp://hdl.handle.net/11449/21392
dc.identifier.wosWOS:000085340500010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Genetics and Cytogenetics
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleDetection of numerical chromosome anomalies in interphase cells of benign and malignant thyroid lesions using fluorescence in situ hybridizationen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

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