Beta-lactam resistance and the effectiveness of antimicrobial peptides against KPC-producing bacteria

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dc.contributor.authorda Costa de Souza, Guilherme [UNESP]
dc.contributor.authorRoque-Borda, Cesar Augusto [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-02T12:25:11Z
dc.date.available2023-03-02T12:25:11Z
dc.date.issued2022-01-01
dc.description.abstractBacterial resistance is a problem that is giving serious cause for concern because bacterial strains such as Acinetobacter baumannii and Pseudomonas aeruginosa are difficult to treat and highly opportunistic. These bacteria easily acquire resistance genes even from other species, which confers greater persistence and tolerance towards conventional antibiotics. These bacteria have the highest death rate in hospitalized intensive care patients, so strong measures must be taken. In this review, we focus on the use of antimicrobial peptides (AMPs) as an alternative to traditional drugs, due to their rapid action and lower risk of generating resistance by microorganisms. We also present an overview of beta-lactams and explicitly explain the activity of AMPs against carbapenemase-producing bacteria as potential alternative agents for infection control.en
dc.description.affiliationSchool of Pharmaceutical Sciences Tuberculosis Research Laboratory São Paulo State University
dc.description.affiliationUnespSchool of Pharmaceutical Sciences Tuberculosis Research Laboratory São Paulo State University
dc.identifierhttp://dx.doi.org/10.1002/ddr.21990
dc.identifier.citationDrug Development Research.
dc.identifier.doi10.1002/ddr.21990
dc.identifier.issn1098-2299
dc.identifier.issn0272-4391
dc.identifier.scopus2-s2.0-85137247259
dc.identifier.urihttp://hdl.handle.net/11449/242239
dc.language.isoeng
dc.relation.ispartofDrug Development Research
dc.sourceScopus
dc.subjectantimicrobial peptides
dc.subjectantimicrobial resistance
dc.subjectcarbapenemase
dc.titleBeta-lactam resistance and the effectiveness of antimicrobial peptides against KPC-producing bacteriaen
dc.typeResenha
unesp.author.orcid0000-0002-9262-0383[2]
unesp.author.orcid0000-0002-6969-3963[3]

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