Characterization of the antinociceptive and sedative effect of amitraz in horses

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dc.contributor.authorQueiroz-Neto, A. [UNESP]
dc.contributor.authorZamur, G. [UNESP]
dc.contributor.authorGonçalves, S. C. [UNESP]
dc.contributor.authorCarregaro, A. B. [UNESP]
dc.contributor.authorMataqueiro, M. I. [UNESP]
dc.contributor.authorHarkins, J. D.
dc.contributor.authorTobin, T.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Kentucky
dc.date.accessioned2014-05-27T11:19:37Z
dc.date.available2014-05-27T11:19:37Z
dc.date.issued1998-11-07
dc.description.abstractAmitraz, an acaricide used to control ectoparasites in animals has a complex pharmacological activity, including α2-adrenergic agonist action. The purpose of this research was to investigate the possible antinociceptive and/or sedative effect of amitraz in horses. The sedative effect of the intravenous (i.v.) injection of dimethylformamide (DMF, 5 mL, control) or amitraz (0.05, 0.10, 0.15 mg/kg), was investigated on the head ptosis test. The participation of α2-adrenergic receptors in the sedative effect provoked by amitraz was studied by dosing yohimbine (0.12 mg/kg, i.v.). To measure the antinociception, xylazine hydrochloride (1 mg/kg, i.v., positive control) and the same doses of amitraz and DMF were used. A focused radiant light/heat directed onto the fetlock and withers of a horse were used as a noxious stimulus to measure the hoof withdrawal reflex latency (HWRL) and the skin twitch reflex latency (STRL). The three doses of amitraz used (0.05, 0.10 and 0.15 mg/kg) provoked a dose-dependent relaxation of the cervical muscles. The experiments with amitraz and xylazine on the HWRL showed that after i.v. administration of all doses of amitraz there was a significant increase of HWRL up to 150 min after the injections. Additionally, there was a significant difference between control (DMF) and positive control (xylazine) values up to 30 min after drug injection. On the other hand, the experiments on the STRL show that after administration of amitraz at the dose of 0.15 mg/kg, a significant increase in STRL was observed when compared with the control group. This effect lasted up to 120 min after injection. However, no significant antinociceptive effect was observed with the 0.05 and 0.10 mg/kg doses of amitraz or at the 1.0 mg/kg dose of xylazine.en
dc.description.affiliationFaculdade Cie. Agrarias Veterinarias Câmpus de Jaboticabal FCAV/UNESP, 14870-000, Jaboticabal, SP
dc.description.affiliationGluck Equine Research Center University of Kentucky, Lexington, KY
dc.description.affiliationUnespFaculdade Cie. Agrarias Veterinarias Câmpus de Jaboticabal FCAV/UNESP, 14870-000, Jaboticabal, SP
dc.format.extent400-405
dc.identifierhttp://dx.doi.org/10.1046/j.1365-2885.1998.00150.x
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics, v. 21, n. 5, p. 400-405, 1998.
dc.identifier.doi10.1046/j.1365-2885.1998.00150.x
dc.identifier.issn0140-7783
dc.identifier.scopus2-s2.0-0031764437
dc.identifier.urihttp://hdl.handle.net/11449/65549
dc.identifier.wosWOS:000076759000011
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.ispartofjcr1.441
dc.relation.ispartofsjr0,700
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectacaricide
dc.subjectalpha 2 adrenergic receptor
dc.subjectalpha 2 adrenergic receptor stimulating agent
dc.subjectamitraz
dc.subjectn,n dimethylformamide
dc.subjectxylazine
dc.subjectyohimbine
dc.subjectantinociception
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectectoparasite
dc.subjectfemale
dc.subjecthorse
dc.subjecthuman experiment
dc.subjectintravenous drug administration
dc.subjectlatent period
dc.subjectmuscle relaxation
dc.subjectneck muscle
dc.subjectnociceptive stimulation
dc.subjectnonhuman
dc.subjectnormal human
dc.subjectpriority journal
dc.subjectptosis
dc.subjectsedation
dc.subjectskin
dc.subjectwithdrawal reflex
dc.subjectAdrenergic alpha-Agonists
dc.subjectAnimals
dc.subjectDimethylformamide
dc.subjectDose-Response Relationship, Drug
dc.subjectFemale
dc.subjectHorses
dc.subjectHypnotics and Sedatives
dc.subjectInjections, Intramuscular
dc.subjectPain Threshold
dc.subjectReceptors, Adrenergic, alpha-2
dc.subjectToluidines
dc.subjectXylazine
dc.subjectAnimalia
dc.subjectEquidae
dc.subjectEquus caballus
dc.titleCharacterization of the antinociceptive and sedative effect of amitraz in horsesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.orcid0000-0002-0580-0467[4]
unesp.author.orcid0000-0002-3643-8958[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV