Preliminary cryocrystallography analysis of an eumenine mastoparan toxin isolated from the venom of the wasp Anterhynchium flavomarginatum micado

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dc.contributor.authorDelatorre, P.
dc.contributor.authorOlivieri, JR
dc.contributor.authorNeto, JR
dc.contributor.authorLorenzi, CCB
dc.contributor.authorCanduri, F.
dc.contributor.authorFadel, V
dc.contributor.authorKonno, K.
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.authorYamane, T.
dc.contributor.authorde Azevedo, W. F.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionFEB
dc.contributor.institutionCtr Univ Votuporanga
dc.date.accessioned2014-05-20T13:12:47Z
dc.date.available2014-05-20T13:12:47Z
dc.date.issued2001-02-09
dc.description.abstractMastoparans are tetradecapeptides found to be the major component of vespid venoms. These peptides present a wide spectrum of biological activities, such as mast cell degranulation, hemolytic activity and also reveals antimicrobial activity. A mastoparan toxin isolated from the venom of Anterhynchium flavomarginatum micado has been crystallized. At room temperature these crystals diffracted to 2.8 Angstrom resolution. However, upon cooling to cryogenic temperature around 85 K, the original resolution limit could be improved to 2.0 Angstrom. Crystals were determined to belong to the space group P3(1) (P3(2)). This is the first mastoparan to be crystallized and it will provide further insights in the conformational significance of mastoparan toxins, with respect to their potency and activity in G protein regulation. (C) 3001 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUNESP, IBILCE, Dept Fis, BR-15054000 Sao Jose Rio Preto, SP, Brazil
dc.description.affiliationUNESP, Inst Biosci Rio Claro, CEIS, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationInstituto Butantan, Div Mol Toxinol, São Paulo, Brazil
dc.description.affiliationFEB, Faciba, Dept Fis, BR-14783226 Barretos, SP, Brazil
dc.description.affiliationCtr Univ Votuporanga, BR-15500030 Votuporanga, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Fis, BR-15054000 Sao Jose Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biosci Rio Claro, CEIS, BR-13506900 Rio Claro, SP, Brazil
dc.format.extent372-376
dc.identifierhttp://dx.doi.org/10.1016/S0167-4838(00)00192-8
dc.identifier.citationBiochimica Et Biophysica Acta-protein Structure and Molecular Enzymology. Amsterdam: Elsevier B.V., v. 1545, n. 1-2, p. 372-376, 2001.
dc.identifier.doi10.1016/S0167-4838(00)00192-8
dc.identifier.issn0167-4838
dc.identifier.lattes2406867656111498
dc.identifier.lattes2835029061696580
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/714
dc.identifier.wosWOS:000167072700038
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica Et Biophysica Acta-protein Structure and Molecular Enzymology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmastoparanpt
dc.subjectcryocrystallographypt
dc.subjectsynchrotronpt
dc.subjectwasppt
dc.titlePreliminary cryocrystallography analysis of an eumenine mastoparan toxin isolated from the venom of the wasp Anterhynchium flavomarginatum micadoen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2406867656111498
unesp.author.lattes2835029061696580
unesp.author.lattes2901888624506535
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Física - IBILCE
Rio Claro - CEIS - Centro de Estudos de Insetos Sociais