Cissus sicyoides (princess vine) in the long-term treatment of streptozotocin-diabetic rats

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dc.contributor.authorPepato, Maria Teresa [UNESP]
dc.contributor.authorBaviera, Amanda Martins [UNESP]
dc.contributor.authorVendramini, Regina Célia [UNESP]
dc.contributor.authorda Silva Perez, MDP
dc.contributor.authorKettelhut, I. D.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:24:26Z
dc.date.available2014-05-20T13:24:26Z
dc.date.issued2003-02-01
dc.description.abstractLeaf decoctions of Cissus sicyoides (princess vine) are taken widely as a popular remedy for diabetes mellitus in Brazil, where its common name is 'vegetal insulin'. However, there have been practically no attempts so far to determine scientifically whether it has antidiabetic effects and we decided to administer leaf decoctions, over extended periods, to normal and streptozotocin-diabetic rats, and investigate the effects of this treatment on the physiological and metabolic parameters that are altered in diabetic animals. The experimental model adopted was shown to be appropriate by running a parallel treatment with insulin, which led to expected improvements in several abnormal parameter values. The decoction treatment significantly reduced the intake of both food and fluid and the volume of urine excreted, as well as the levels of blood glucose, urinary glucose and urinary urea, in comparison with controls. Lipid metabolism was not affected by the treatment; nor was the level of hepatic glycogen in diabetic animals, which indicated that the mechanism responsible for the improvement in carbohydrate metabolism, observed in animals treated with the decoction, could not involve inhibition of glycogenolysis and/or stimulation of glycogenesis. The fact that normal animals treated with C. sicyoides exhibited no changes in any of the measured parameters suggests that its mode of action in diabetic animals does not resemble those of sulphonylurea or insulin. It may, however, act in a similar way to biguanide, via inhibition of gluconeogenesis.en
dc.description.affiliationUNESP, Dept Anal Clin, Fac Ciências Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Bioquim, BR-05508 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Dept Anal Clin, Fac Ciências Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.format.extent15-20
dc.identifierhttp://dx.doi.org/10.1042/BA20020065
dc.identifier.citationBiotechnology and Applied Biochemistry. London: Portland Press, v. 37, p. 15-20, 2003.
dc.identifier.doi10.1042/BA20020065
dc.identifier.issn0885-4513
dc.identifier.lattes3736475025187750
dc.identifier.lattes7641979287850489
dc.identifier.urihttp://hdl.handle.net/11449/7580
dc.identifier.wosWOS:000181189200003
dc.language.isoeng
dc.publisherPortland Press
dc.relation.ispartofApplied Biochemistry and Biotechnology
dc.relation.ispartofjcr1.440
dc.relation.ispartofsjr0,431
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanti-diabetic activitypt
dc.subjectanti-diabetic plantpt
dc.subjectgluconeogenesispt
dc.subjectplasma glucosept
dc.subjectvegetal insulinpt
dc.titleCissus sicyoides (princess vine) in the long-term treatment of streptozotocin-diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.portlandpress.com/pp/journals/rights.htm
dcterms.rightsHolderPortland Press
unesp.author.lattes3736475025187750[2]
unesp.author.lattes7641979287850489
unesp.author.orcid0000-0003-0987-5295[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR