Assessment of redox state and biochemical parameters of salivary glands in streptozotocin-induced diabetic male rats treated with mate tea (Ilex paraguariensis)

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dc.contributor.authorGomes, Marco Aurélio [UNESP]
dc.contributor.authorManzano, Carolina [UNESP]
dc.contributor.authorAlves, Thayane Miranda [UNESP]
dc.contributor.authorFiais, Gabriela Alice [UNESP]
dc.contributor.authorFreitas, Rayara Nogueira [UNESP]
dc.contributor.authorCoutinho Mattera, Maria Sara de Lima [UNESP]
dc.contributor.authorDornelles, Rita Cássia Menegati [UNESP]
dc.contributor.authorMatsushita, Doris Hissako [UNESP]
dc.contributor.authorStevanato Nakamune, Ana Cláudia de Melo [UNESP]
dc.contributor.authorChaves-Neto, Antonio Hernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T14:12:37Z
dc.date.available2023-07-29T14:12:37Z
dc.date.issued2022-11-01
dc.description.abstractObjective: The study aimed to assess the effects of mate tea [Ilex paraguariensis] on the redox state and biochemical parameters of salivary glands in diabetic male rats. Design: Twenty-four male Wistar rats (3 months old) were randomly divided into groups (n = 8 per group): control rats that received water (C); diabetic rats that received water (D); diabetic rats treated with mate tea (DMT). The treated streptozotocin-induced diabetic rats were given mate tea powder by intragastric gavage at a dose of 20 mg/kg daily for 28 days. Content of total protein, amylase, oxidative lipid damage, measured as thiobarbituric acid reactive substances (TBARs), oxidative protein damage, measured as protein carbonyl, total antioxidant capacity, uric acid, reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were examined by the spectrophotometric method in the parotid and submandibular glands. Results: The D group showed lower total protein, amylase, TBARs, protein carbonyl, total antioxidant capacity, GSH, uric acid, and GPx than the C group in both salivary glands, as well as higher SOD and CAT activities. The DMT group showed higher total protein, amylase, total antioxidant capacity, GSH, uric acid, and GPx than the D group in both salivary glands. Moreover, mate tea increased SOD in the parotid gland and CAT in the submandibular gland of diabetic rats but did not influence TBARs and protein carbonyl in either salivary gland compared to D group. Conclusion: Mate tea increased tissue protein synthesis and improved antioxidant defenses in the salivary glands of streptozotocin-induced diabetic male rats.en
dc.description.affiliationDepartamento de Ciências Básicas Universidade Estadual Paulista (Unesp) Faculdade de Odontologia, São Paulo
dc.description.affiliationPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas – SBFis Universidade Estadual Paulista (Unesp) Faculdade de Odontologia, São Paulo
dc.description.affiliationPrograma de Pós-Graduação em Ciência Odontológica– Saúde Bucal da Criança Universidade Estadual Paulista (Unesp) Faculdade de Odontologia, São Paulo
dc.description.affiliationUnespDepartamento de Ciências Básicas Universidade Estadual Paulista (Unesp) Faculdade de Odontologia, São Paulo
dc.description.affiliationUnespPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas – SBFis Universidade Estadual Paulista (Unesp) Faculdade de Odontologia, São Paulo
dc.description.affiliationUnespPrograma de Pós-Graduação em Ciência Odontológica– Saúde Bucal da Criança Universidade Estadual Paulista (Unesp) Faculdade de Odontologia, São Paulo
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdUniversidade Estadual Paulista: 158/006/2018-PROPe
dc.description.sponsorshipIdUniversidade Estadual Paulista: 2017/41476-PIBIC/RT
dc.description.sponsorshipIdCNPq: 2018/46604
dc.description.sponsorshipIdUniversidade Estadual Paulista: 284/001/2017-PROPe
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105551
dc.identifier.citationArchives of Oral Biology, v. 143.
dc.identifier.doi10.1016/j.archoralbio.2022.105551
dc.identifier.issn1879-1506
dc.identifier.issn0003-9969
dc.identifier.scopus2-s2.0-85138600295
dc.identifier.urihttp://hdl.handle.net/11449/249188
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectDiabetes Mellitus
dc.subjectExperimental
dc.subjectIlex paraguariensis
dc.subjectParotid gland
dc.subjectSubmandibular gland
dc.titleAssessment of redox state and biochemical parameters of salivary glands in streptozotocin-induced diabetic male rats treated with mate tea (Ilex paraguariensis)en
dc.typeArtigo

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