Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode

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dc.contributor.authorJorge, S. M. A. [UNESP]
dc.contributor.authorPontinha, A. D. R.
dc.contributor.authorOliveira-Brett, A. M.
dc.contributor.institutionUniv Coimbra
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:53:34Z
dc.date.available2014-05-20T13:53:34Z
dc.date.issued2010-03-01
dc.description.abstractThe electrochemical redox behavior of omeprazole (OMZ), a gastric acid pump inhibitor, was investigated at a glassy carbon electrode using cyclic, differential pulse and square-wave voltammetry over a wide pH range. The pH-dependent oxidation occurs in two irreversible consecutive charge transfer reactions. Adsorption of the non-electroactive product was also observed. The first oxidation involves removal of one electron, followed by deprotonation and leads to the formation of a hydroxylated species. The second oxidation process is related to the hydroxyl and amino groups in the benzimidazole moiety. The reduction is irreversible, also pH-dependent, and occurs in a single step at the sulfoxide group in a diffusion-controlled mechanism. The diffusion coefficient of omeprazole was calculated to be D(OMZ) = 2.31 x 10(-6) cm(2) s(-1).en
dc.description.affiliationUniv Coimbra, Fac Ciencias & Tecnol, Dept Quim, P-3004535 Coimbra, Portugal
dc.description.affiliationUNESP, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)
dc.description.sponsorshipPOCI
dc.description.sponsorshipEuropean Community Fund FEDER
dc.description.sponsorshipCEMUC-R
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFCT: SFRH/BD/46026/2008
dc.description.sponsorshipIdFCT: PTDC/QUI/65255/2006
dc.description.sponsorshipIdCEMUC-R: 285
dc.description.sponsorshipIdCAPES: 1211-08-0
dc.format.extent625-631
dc.identifierhttp://dx.doi.org/10.1002/elan.200900377
dc.identifier.citationElectroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 22, n. 6, p. 625-631, 2010.
dc.identifier.doi10.1002/elan.200900377
dc.identifier.issn1040-0397
dc.identifier.lattes5216150705972509
dc.identifier.urihttp://hdl.handle.net/11449/19120
dc.identifier.wosWOS:000275803200004
dc.language.isoeng
dc.publisherWiley-v C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.ispartofjcr2.851
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectOmeprazoleen
dc.subjectElectrochemistryen
dc.subjectOxidationen
dc.subjectReductionen
dc.titleElectrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrodeen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-v C H Verlag Gmbh
unesp.author.lattes5216150705972509
unesp.author.orcid0000-0002-6244-0891[3]
unesp.author.orcid0000-0002-0400-4645[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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