Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode
dc.contributor.author | Jorge, S. M. A. [UNESP] | |
dc.contributor.author | Pontinha, A. D. R. | |
dc.contributor.author | Oliveira-Brett, A. M. | |
dc.contributor.institution | Univ Coimbra | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:53:34Z | |
dc.date.available | 2014-05-20T13:53:34Z | |
dc.date.issued | 2010-03-01 | |
dc.description.abstract | The electrochemical redox behavior of omeprazole (OMZ), a gastric acid pump inhibitor, was investigated at a glassy carbon electrode using cyclic, differential pulse and square-wave voltammetry over a wide pH range. The pH-dependent oxidation occurs in two irreversible consecutive charge transfer reactions. Adsorption of the non-electroactive product was also observed. The first oxidation involves removal of one electron, followed by deprotonation and leads to the formation of a hydroxylated species. The second oxidation process is related to the hydroxyl and amino groups in the benzimidazole moiety. The reduction is irreversible, also pH-dependent, and occurs in a single step at the sulfoxide group in a diffusion-controlled mechanism. The diffusion coefficient of omeprazole was calculated to be D(OMZ) = 2.31 x 10(-6) cm(2) s(-1). | en |
dc.description.affiliation | Univ Coimbra, Fac Ciencias & Tecnol, Dept Quim, P-3004535 Coimbra, Portugal | |
dc.description.affiliation | UNESP, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil | |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (FCT) | |
dc.description.sponsorship | POCI | |
dc.description.sponsorship | European Community Fund FEDER | |
dc.description.sponsorship | CEMUC-R | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | FCT: SFRH/BD/46026/2008 | |
dc.description.sponsorshipId | FCT: PTDC/QUI/65255/2006 | |
dc.description.sponsorshipId | CEMUC-R: 285 | |
dc.description.sponsorshipId | CAPES: 1211-08-0 | |
dc.format.extent | 625-631 | |
dc.identifier | http://dx.doi.org/10.1002/elan.200900377 | |
dc.identifier.citation | Electroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 22, n. 6, p. 625-631, 2010. | |
dc.identifier.doi | 10.1002/elan.200900377 | |
dc.identifier.issn | 1040-0397 | |
dc.identifier.lattes | 5216150705972509 | |
dc.identifier.uri | http://hdl.handle.net/11449/19120 | |
dc.identifier.wos | WOS:000275803200004 | |
dc.language.iso | eng | |
dc.publisher | Wiley-v C H Verlag Gmbh | |
dc.relation.ispartof | Electroanalysis | |
dc.relation.ispartofjcr | 2.851 | |
dc.relation.ispartofsjr | 0,692 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Omeprazole | en |
dc.subject | Electrochemistry | en |
dc.subject | Oxidation | en |
dc.subject | Reduction | en |
dc.title | Electrochemical Redox Behavior of Omeprazole Using a Glassy Carbon Electrode | en |
dc.type | Artigo | |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dcterms.rightsHolder | Wiley-v C H Verlag Gmbh | |
unesp.author.lattes | 5216150705972509 | |
unesp.author.orcid | 0000-0002-6244-0891[3] | |
unesp.author.orcid | 0000-0002-0400-4645[2] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatu | pt |
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