Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19

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dc.contributor.authorde Moraes, Diogo [UNESP]
dc.contributor.authorPaiva, Brunno Vivone Buquete [UNESP]
dc.contributor.authorCury, Sarah Santiloni [UNESP]
dc.contributor.authorLudwig, Raissa Guimarães
dc.contributor.authorJunior, João Pessoa Araújo [UNESP]
dc.contributor.authorda Silva Mori, Marcelo Alves
dc.contributor.authorCarvalho, Robson Francisco [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2021-06-25T11:10:56Z
dc.date.available2021-06-25T11:10:56Z
dc.date.issued2021-01-01
dc.description.abstractCOVID-19 is prevalent in the elderly. Old individuals are more likely to develop pneumonia and respiratory failure due to alveolar damage, suggesting that lung senescence may increase the susceptibility to SARS-CoV-2 infection and replication. Considering that human coronavirus (HCoVs; SARS-CoV-2 and SARS-CoV) require host cellular factors for infection and replication, we analyzed Genotype-Tissue Expression (GTEx) data to test whether lung aging is associated with transcriptional changes in human protein-coding genes that potentially interact with these viruses. We found decreased expression of the gene tribbles homolog 3 (TRIB3) during aging in male individuals, and its protein was predicted to interact with HCoVs nucleocapsid protein and RNA-dependent RNA polymerase. Using publicly available lung single-cell data, we found TRIB3 expressed mainly in alveolar epithelial cells that express SARS-CoV-2 receptor ACE2. Functional enrichment analysis of age-related genes, in common with SARS-CoV-induced perturbations, revealed genes associated with the mitotic cell cycle and surfactant metabolism. Given that TRIB3 was previously reported to decrease virus infection and replication, the decreased expression of TRIB3 in aged lungs may help explain why older male patients are related to more severe cases of the COVID-19. Thus, drugs that stimulate TRIB3 expression should be evaluated as a potential therapy for the disease.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationFaculty of Medicine São Paulo State University UNESP
dc.description.affiliationDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Biochemistry and Tissue Biology Institute of Biology State University of Campinas (UNICAMP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationUnespFaculty of Medicine São Paulo State University UNESP
dc.description.affiliationUnespDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)
dc.format.extent42-49
dc.identifierhttp://dx.doi.org/10.14336/AD.2020.1112
dc.identifier.citationAging and Disease, v. 12, n. 1, p. 42-49, 2021.
dc.identifier.doi10.14336/AD.2020.1112
dc.identifier.issn2152-5250
dc.identifier.scopus2-s2.0-85100290140
dc.identifier.urihttp://hdl.handle.net/11449/208365
dc.language.isoeng
dc.relation.ispartofAging and Disease
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectLung aging
dc.subjectSARS-CoV-2
dc.subjectTribbles homolog 3
dc.subjectα-hydroxylinoleic acid
dc.titlePrediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19en
dc.typeArtigo

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