Low toxic effects of a whitening strip to cultured pup cells

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dc.contributor.authorSoares, Diana Gabriela de Souza [UNESP]
dc.contributor.authorPontes, Elaine Cristina Voltolini [UNESP]
dc.contributor.authorRibeiro, Ana Paula Dias
dc.contributor.authorBasso, Fernanda Gonçalves [UNESP]
dc.contributor.authorHebling, Josimeri [UNESP]
dc.contributor.authorCosta, Carlos Alberto de Souza [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.date.accessioned2015-08-06T16:12:11Z
dc.date.available2015-08-06T16:12:11Z
dc.date.issued2013
dc.description.abstractTo assess the trans-enamel and trans-dentin toxicity of a 10% hydrogen peroxide (HP) whitening strip to odontoblast-like cells (MDPC-23). Methods: Enamel surfaces of enamel/dentin discs adapted to artificial pulp chambers were subjected to two 30-minute whitening strip applications to obtain indirect extracts (DMEM + bleaching components that diffused across enamel and dentin). The extracts were applied for 1 hour to the cells for 1 or 5 days. A bleaching gel with 35% HP was used as the positive control. Cell viability (MTT assay) and morphology (SEM) as well as the quantity of HP in the extracts were assessed. Results: Discrete cell viability reduction (21.9%) associated with slight alterations in cell morphology occurred after application of the extracts for 5 days to the MDPC-23 cells (Tukey's test; P< 0.05). Lower enamel/dentin diffusion of HP was observed after the use of the whitening strip compared with the bleaching gel (Mann-Whitney; P< 0.05).en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Infantil, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801-903, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Infantil, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801-903, SP, Brasil
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipIdFAPESP: 2011/12938-8
dc.description.sponsorshipIdFAPESP: 2011/09385-7
dc.description.sponsorshipIdCNPq: 301029/2010-1
dc.format.extent283-285
dc.identifierhttp://www.amjdent.com/previousarticles.htm
dc.identifier.citationAmerican Journal of Dentistry, v. 26, p. 283-285, 2013.
dc.identifier.issn0894-8275
dc.identifier.lattes1531215699841687
dc.identifier.lattes5087114843448227
dc.identifier.lattes8207097271172991
dc.identifier.lattes4517484241515548
dc.identifier.urihttp://hdl.handle.net/11449/125476
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Dentistry
dc.relation.ispartofjcr0.760
dc.relation.ispartofsjr0,509
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectRandomized clinical-trialen
dc.subjectBleaching gelen
dc.subjectIn-vitroen
dc.subjectPeroxide penetrationen
dc.subjectCarbamide peroxideen
dc.subjectHydrogen-peroxideen
dc.subjectMdpc-23 cellsen
dc.subjectEfficacyen
dc.subjectOfficeen
dc.subjectProductsen
dc.titleLow toxic effects of a whitening strip to cultured pup cellsen
dc.typeArtigo
unesp.author.lattes1531215699841687
unesp.author.lattes5087114843448227
unesp.author.lattes8207097271172991
unesp.author.lattes4517484241515548[6]
unesp.author.orcid0000-0002-7455-6867[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologiapt
unesp.departmentMateriais Odontológicos e Prótesept
unesp.departmentClínica Infantilpt

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